Battle of the Insulins: Thrice-Daily Novomix vs. Once-Daily Insulin Glargine in Managing Glycemic Control for Type 2 Diabetes

Articles in Press

Document Type : Original Article(s)

Authors

1 1. Faculty of Medicine - Shahid Sadoughi University of Medical Sciences, Yazd. Iran

2 2- Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

10.48305/jims.2025.45272.2491

Abstract

Introduction: Type 2 diabetes mellitus (T2DM) is a major public health issue in Iran, affecting 1.3% to 14.5% of the population. Management includes lifestyle modifications, oral antihyperglycemic agents, and insulin therapy. This study compares the efficacy and safety of Novomix insulin with a regimen of insulin glargine and aspart for improving glycemic control in Iranian T2DM patients.
Materials & Methods: A cross-sectional study at Yazd Medical Research Center included participants aged 30 and older with T2DM for over a year. Patients used either Novomix insulin or insulin glargine plus aspart, with specific kidney function criteria (GFR <30). Glycemic control data (HbA1c, fasting blood glucose, and 2hPP glucose) were collected at baseline, 24, and 48 weeks. Ethical approval was granted by Shahid Sadougi University. (IR.SSU. MEDICINE.REC.1399.198).
Results: A total of 243 patients participated, with 130 assigned to the glargine plus aspart group and 113 to the Novomix group. Baseline glycemic measurements were comparable (P>0.05). Both regimens achieved significant reductions in FBG, 2hPP, and HbA1c levels from baseline to 24 and 48 weeks (P<0.05). However, the differences in the changes between the two groups were not statistically significant (P>0.05).
Conclusion: Both insulin regimens effectively lowered glycemic levels without significant differences. Future studies with larger samples and longer durations are needed for further evaluation.

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Reyhaneh Azizi: Google Scholar

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Journal of Isfahan Medical School

Articles in Press, Accepted Manuscript
Available Online from 02 September 2025

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History

  • Receive Date: 02 June 2025
  • Accept Date: 10 June 2025

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