مقایسه‌ی اثربخشی ویتامین دی، توانبخشی شناختی، تحریک جریان متناوب مغز و ترکیب درمان توانبخشی شناختی و تحریک جریان متناوب مغز بر افسردگی سالمندان مبتلا به نقص شناختی خفیف

نوع مقاله : Original Article(s)

نویسندگان

1 دانشجوی دکتری روانشناسی، گروه روانشناسی، دانشکده‌ی ادبیات و علوم انسانی، دانشگاه لرستان، لرستان، ایران

2 دانشیار، گروه روانشناسی، دانشکده‌ی ادبیات و علوم انسانی، دانشگاه لرستان، لرستان، ایران

3 استاد، گروه روانشناسی، دانشکده‌ی ادبیات و علوم انسانی، دانشگاه لرستان، لرستان، ایران

4 دانشیار، گروه پزشکی داخلی، بیمارستان آیت الله طالقانی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران

10.48305/jims.v42.i755.0058

چکیده

مقاله پژوهشی




مقدمه: افسردگی، پیش‌بینی‌کننده‌ی نقص شناختی در افراد سالمند می‌باشد. هدف پژوهش حاضر، بررسی و مقایسه‌ی اثربخشی ویتامین D، توانمندسازی شناختی (Cognitive rehabilitation therapy) CRT، تحریک فراجمجمه‌ای مغز (transcranial alternating current stimulation) tACS و ترکیب دو درمان (CRT+tACS) بر کاهش افسردگی سالمندان مبتلا به نقص شناختی خفیف بود.
روش‌ها: پژوهش حاضر یک مطالعه‌ی کارآزمایی بالینی نیمه تجربی است که 32 فرد دارای نقص شناختی خفیف بعد از تکمیل تست افسردگی Beck
(Beck Depression Inventory) BDI و (Montreal Cognitive Assessment) MoCA در چهار گروه درمانی بصورت تصادفی اختصاص داده شدند. مداخله‌ی CRT، tACS و CRT+tACS هر کدام ۱۲ جلسه و هفته‌ای دوبار برگزار گردید. هر جلسه CRT و tACS۲۰ دقیقه و هر جلسه درمان توانبخشی شناختی بعلاوه tACS به مدت ۴۰ دقیقه اجرا گردید و در گروه دریافت ویتامین D به مدت ۶ هفته روزانه ۲۰ میکروگرم معادل با ۸۰۰ IU ویتامین D دریافت کردند. قبل از انجام پژوهش تست افسردگی Beck (BDI) و تست MoCA و در پایان پژوهش BDI گرفته شد تا اثربخشی درمان‌ها بر کاهش افسردگی بررسی شود. به منظور تحلیل نتایج از آزمون آماری اندازه‌گیری مکرر با سطح معنی‌داری کمتر از 0/05 مختلط استفاده شد.
یافته‌ها: بر اساس نتایج بدست آمده در گروه‌CRT  شاهد کاهش معنی‌دار نمرات افسردگی بک از ۱۱ به ۹ بودیم. در گروه ACS، CRT+tACS و ویتامین D تفاوت بین نمرات افسردگی معنی‌دار نبود.
نتیجه‌گیری: بر اساس مطالعه‌ی حاضر، CRT باعث کاهش نمره‌ی افسردگی در بین افراد دارای نقص شناختی خفیف می‌شود و این درمان در مقایسه با tACS، CRT+tACS و ویتامین D مؤثرتر بود.

تازه های تحقیق

فریبا ابراهیم بابایی: Google Scholar

کورش امرایی: Google Scholar, PubMed

فیروزه غضنفری: Google Scholar, PubMed

پریسا طاهری تنجانی: Google Scholar, PubMed

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Comparison of the Effectiveness of Vitamin D, Integrated Cognitive Rehabilitation Therapy, Transcranial Alternating Current Stimulation on Depression in Patients with Mild Cognitive Impairment

نویسندگان [English]

  • Fariba Ebrahimbabaie 1
  • Kourosh Amraei 2
  • Firoozeh Ghazanfari 3
  • Parisa Taheri Tanjani 4
1 PhD Student, Department of Psychology, School of Literature and Humanities’Sciences, Lorestan University, Lorestan, Iran
2 Associate Professor, Department of Psychology, School of Literature and Humanities’Sciences, Lorestan University, Lorestan, Iran
3 Professor, Department of Psychology, School of Literature and Humanities’Sciences, Lorestan University, Lorestan, Iran
4 Associate Professor, Department of Internal Medicine, Ayatollah Taleghani Hospital, Research Development Unit, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده [English]

Background: Depression is a predictor of cognitive impairment in aged people. This study aimed to compare the effect of Vitamin D, integrated cognitive rehabilitation therapy (CRT), transcranial alternating current stimulation (tACS), and a combination of CRT and tACS on depression in patients with mild cognitive impairment (MCI).
Methods: The present study is a semi-experimental clinical trial study in which 32 people with mild cognitive impairment were randomly assigned to four treatment groups after completing the Beck Depression Test and the Mocha Test. CRT, tACS, and CRT + tACS interventions were held twice a week for 12 sessions each. Each session of CRT and tACS lasted 20 minutes, and each session of cognitive rehabilitation treatment plus TACS was performed for 40 minutes, and the group receiving vitamin D; received 20 micrograms equivalent to 800 IU of vitamin D daily for six weeks. Before conducting the research, the Beck depression test (BDI) and MoCA test were taken, and at the end of the research, BDI was taken to check the effectiveness of treatments on reducing depression. To analyze the results, the repeated measurement statistical test with a significance level of less than 0.05 was used.
Findings: The results showed that the depression scores decreased significantly in the cognitive rehabilitation intervention group from 11 to 9. However, no significant difference was observed in the transcranial alternating current stimulation (tACS) and combination of CRT and tACS and vitamin D groups.
Conclusion: According to the present study, CRT decreased depression scores in MCI, and it is more effective in reducing depression compared to tACS, CRT+tACS, and vitamin D.

کلیدواژه‌ها [English]

  • Cognitive Dysfunction
  • Impairment
  • Vitamin D
  • Cognitive training
  • Transcranial alternating current stimulation
  • Depression

مراجع

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مجله دانشکده پزشکی اصفهان
دوره 42، شماره 755
هفته 3، فروردین
فروردین و اردیبهشت 1403
صفحه 58-68

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  • تاریخ دریافت: 28 مرداد 1402
  • تاریخ بازنگری: 14 بهمن 1402
  • تاریخ پذیرش: 14 بهمن 1402

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