The Frequency of Diabetic Nephropathy in Children and Adolescents with Type 1 Diabetes Mellitus

Document Type : Original Article (s)

Authors

1 Assistant Professor, Isfahan Endocrine and Metabolism Research Center AND Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease AND Imam Hossein Children's Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

2 Student of Medicine, Student Research Committee, School of Medicine AND Imam Hossein Children's Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

3 Professor, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease AND Isfahan Endocrine and Metabolism Research Center AND Imam Hossein Children's Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

4 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

5 Assistant Professor, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Diabetes mellitus is a chronic metabolic disorder caused by insulin secretion disorder. The aim of this study was to determine the distribution of diabetic nephropathy in children and adolescents with type 1 diabetes mellitus in Isfahan City, Iran.Methods: In this cross-sectional study conducted in 2018, in the Pediatric Endocrinology Clinic of Isfahan University of Medical Sciences, 301 patients under the age of 18 years with type 1 diabetes mellitus were selected Then, the ratio of microalbumin to random urinary creatinine, as a method for diagnosis of diabetic nephropathy, was measured, and its relationship with demographic characteristics, clinical history, hemoglobin A1c (HbA1c), and blood pressure was investigated.Findings: Of 301 patients, 12 (4%) had diabetic nephropathy. Among the studied variables, there was a significant relationship between nephropathy with blood glucose control (P = 0.020), mean HbA1c (P < 0.001), and mean systolic blood pressure (P < 0.001).Conclusion: The results of this study showed that the prevalence of diabetic nephropathy in children with type 1 diabetes mellitus in Isfahan was 4%, and some of risk factors such as proper control of blood glucose, systolic blood pressure, and HBA1C levels were significantly associated with it. Therefore, patients with type 1 diabetes mellitus should be monitored for risk factors of nephropathy.

Keywords

References

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Journal of Isfahan Medical School
Volume 37, Issue 529 - Serial Number 529
May and June 2019
Pages 617-623

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History

  • Receive Date: 30 April 2019
  • Revise Date: 20 May 2024
  • Accept Date: 06 April 2022

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