نوع مقاله : ششمین کنگره غدد و متابولیسم
نویسندگان
1 استادیار، مرکز تحقیقات غدد درون‌ریز، دانشگاه علوم پزشکی تبریز، تبریز، ایران
2 استاد، مرکز تحقیقات غدد درون‌ریز، دانشگاه علوم پزشکی تبریز، تبریز، ایران
چکیده
تازه های تحقیق
نعیمه مصری علمداری: Google Scholar, PubMed
مجید مبصری: Google Scholar, PubMed
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Background: As the endocrine and metabolic disorder of women of reproductive age, Polycystic ovarian syndrome (PCOS) is common, with a multifaceted etiology. Insulin dysfunction and hyperandrogenemia are the suggested etiologies. Recent evidence suggests that Royal Jelly (RJ) has anti-androgenic and glucose hemostasis effects in PCOS animal models. This investigation aimed to evaluate the effect of RJ consumption on androgenic hormones, glycemic, inflammatory indices, and clinical signs of women with PCOCS.
Methods: The present clinical trial was conducted on 22 women with PCOS who received either RJ (1000mg/day) or placebo (1000mg/day) for 8 weeks. Study endpoints were evaluating the androgenic hormones, glucose-related parameters, IL-6, CRP, and clinical signs of PCOS, pre-and post-intervention.
Findings: RJ supplementation gave rise to a marked decrement of serum testosterone in the RJ group after adjustment for the confounders (P < 0.001). A significant decrease in levels of CRP was noticed in the intervention arm, relative to placebo at the end of the study following potential confounding factors adjustments (Model 1 P = 0.035, model2 P = 0.003). Regarding clinical signs, there was an improvement in oligomenorrhea and acne severity following RJ supplementation in the PCOS group (P < 0.001, P = 0.022 respectively). Following RJ supplementation for eight weeks, 1 in 4 patient’s acne severity declined in PCOS patients.
Conclusion: It is suggested that RJ supplementation could remarkably ameliorate androgen hormones, inflammation, and clinical signs of patients with PCOS. More investigations with more sample sizes, extensive periods, and distinct doses are suggested.
کلیدواژه‌ها [English]
)