Changes in C-Reactive Protein, Fibrinogen and Lipid Profile in Elderly Men after Eight Weeks of Aerobic Training

Document Type : مقاله کوتاه

Authors

1 Assistant Professor, Department of Physical Education and Sport Science, School of Literature and Humanities, University of Jahrom, Jahrom, Iran

2 Assistant Professor, Department of Exercise Physiology, School of Physical Education and Sport Science, Shiraz Branch, Islamic Azad University, Shiraz, Iran

3 Department of Exercise Physiology, School of Physical Education and Sport Science, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran

Abstract

Background: Increasing in cardiovascular risk factors in old age is known as the most common cause of the dangerous heart problems. This study aimed to assess the changes in C-reactive protein, fibrinogen and lipid profile in elderly men after eight weeks of aerobic training.Methods: 52 men with more than 60 years of age in the park in the city of Shiraz, Iran, were enrolled as volunteers, and based on body mass index were divided in two equal groups of experimental and control. Then, the experimental group participated in a training program for 8 weeks, 6 days per week. To measure the desired parameters, blood samples were taken from participants before and after the study. The data analysis was done using dependent and independent t tests.Findings: Eight weeks of aerobic training significantly decreased fibrinogen (P = 0.001), C-reactive protein (P = 0.001), total cholesterol (P = 0.010) and triglyceride (P = 0.010) and significantly increased high-density lipoprotein (P = 0.006).Conclusion: Eight weeks of aerobic exercise caused a significant decrease in fibrinogen, C-reactive protein, and lipid profile in elderly men and we can use this training program to effectively improve health promotion.

Keywords

References

  1. Amiri M, Farazmand A, Toloei M. Causes of patients' hospitalization in Guilan University hospitals. J Guilan Univ Med Sci 2002; 11(42): 28-32. [In Persian].
  2. Sharifirad GhR, Mohebi S, Matlabi M. The relationship of physical activity in middle age and cardiovascular problems in old age in retired people in Isfahan, 2006. Ofogh-e-Danesh 2007; 13(2): 57-63. [In Persian].
  3. Fox E, Mathews D. Exercise physiology. Trans. Khaledan A. Tehran, Iran: Tehran University Press; 2005. p. 617-34.
  4. Sweetman S. Martindale: The complete drug reference. 35th ed. London, UK: Pharmaceutical Press; 2006. p. 1772-3.
  5. Meyer AA, Kundt G, Lenschow U, Schuff-Werner P, Kienast W. Improvement of early vascular changes and cardiovascular risk factors in obese children after a six-month exercise program. J Am Coll Cardiol 2006; 48(9): 1865-70.
  6. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005; 352(16): 1685-95.
  7. Jafari A, Aghaei F, Nikookheslat S. Effect of an exhaustive exercise and short-term glutamine supplementation on serum hs-CRP, in non-athlete males. Journal Sport and Exercise Physiology 2010; 4(2): 305-14. [In Persian].
  8. Saito M, Ishimitsu T, Minami J, Ono H, Ohrui M, Matsuoka H. Relations of plasma high-sensitivity C-reactive protein to traditional cardiovascular risk factors. Atherosclerosis 2003; 167(1): 73-9.
  9. Flegal KM, Graubard BI, Williamson DF, Gail MH. Excess deaths associated with underweight, overweight, and obesity. JAMA 2005; 293(15): 1861-7.
  10. van Loon LJ. Use of intramuscular triacylglycerol as a substrate source during exercise in humans. J Appl Physiol (1985 ) 2004; 97(4): 1170-87.
  11. Abramson JL, Vaccarino V. Relationship between physical activity and inflammation among apparently healthy middle-aged and older US adults. Arch Intern Med 2002; 162(11): 1286-92.
  12. Wong LY, Leung RY, Ong KL, Cheung BM. Plasma levels of fibrinogen and C-reactive protein are related to interleukin-6 gene -572C>G polymorphism in subjects with and without hypertension. J Hum Hypertens 2007; 21(11): 875-82.
  13. Atashak S, Baturak K, Ghaderi M. Effect of BCAA supplementation on serum C-reactive protein after acute resistance exercise in soccer players. Knowledge Health 2013; 8(1): 12-6. [In Persian].
  14. Roberts WC. HMG-CoA Reductase Inhibitors and Fibrates in the Treatment of Hyperlipidaemia Atherosclerotic risk factors are there ten, or is there only one? Atherosclerosis 1992; 97(Suppl): S5-S9.
  15. Folsom AR, Arnett DK, Hutchinson RG, Liao F, Clegg LX, Cooper LS. Physical activity and incidence of coronary heart disease in middle-aged women and men. Med Sci Sports Exerc 1997; 29(7): 901-9.
  16. Kashef M, Zare Karizak S, Sha'baninia M. Effect of one-session anaerobic exhaustive exercise on lipid profile of active and inactive individuals. Ofogh-e-Danesh 2014; 20(3): 171-7. [In Persian].
  17. Altena TS, Michaelson JL, Ball SD, Guilford BL, Thomas TR. Lipoprotein subfraction changes after continuous or intermittent exercise training. Med Sci Sports Exerc 2006; 38(2): 367-72.
  18. Jahromi AS, Zar A, Ahmadi F, Krustrup P, Ebrahim K, Hovanloo F, et al. Effects of Endurance Training on the Serum Levels of Tumour Necrosis Factor-alpha and Interferon-gamma in Sedentary Men. Immune Netw 2014; 14(5): 255-9.
  19. Jahangard T, Torkaman G, Ghoosheh B, Hedayati M, Dibaj A. The effect of short-term aerobic training on coagulation and fibrinolytic factors in sedentary healthy postmenopausal women. Maturitas 2009; 64(4): 223-7.
  20. Nouri R, Sheykh Sarraf B, Fathollahi shourabe F, Jalali Dehkordi Kh. Effects of 8 weeks exercise trainings on changes in fibrinogen, CRP, leukocytes and cardiovascular fitness in men inactive after leaving drug. Olympic 2013; 21(1): 7-20. [In Persian].
  21. Sattarzadeh L, Peeri M, Azarbayjani M, Homaee HM. The effect of resistance exercise training on inflammatory marker C-reactive protein in healthy untrained women. GMP Review, 2015; 18(1): 308-13.
  22. O'Donovan G, Owen A, Bird SR, Kearney EM, Nevill AM, Jones DW, et al. Changes in cardiorespiratory fitness and coronary heart disease risk factors following 24 wk of moderate- or high-intensity exercise of equal energy cost. J Appl Physiol (1985) 2005; 98(5): 1619-25.
  23. Wilhelmsen L, Svardsudd K, Korsan-Bengtsen K, Larsson B, Welin L, Tibblin G. Fibrinogen as a risk factor for stroke and myocardial infarction. N Engl J Med 1984; 311(8): 501-5.
  24. Dotevall A, Johansson S, Wilhelmsen L. Association between fibrinogen and other risk factors for cardiovascular disease in men and women. Results from the Goteborg MONICA survey 1985. Ann Epidemiol 1994; 4(5): 369-74.
  25. Folsom AR, Wu KK, Davis CE, Conlan MG, Sorlie PD, Szklo M. Population correlates of plasma fibrinogen and factor VII, putative cardiovascular risk factors. Atherosclerosis 1991; 91(3): 191-205.
  26. Geffken DF, Cushman M, Burke GL, Polak JF, Sakkinen PA, Tracy RP. Association between physical activity and markers of inflammation in a healthy elderly population. Am J Epidemiol 2001; 153(3): 242-50.
  27. Yarnell J, McCrum E, Rumley A, Patterson C, Salomaa V, Lowe G, et al. Association of European population levels of thrombotic and inflammatory factors with risk of coronary heart disease: the MONICA Optional Haemostasis Study. Eur Heart J 2005; 26(4): 332-42.
  28. Horowitz JF, Leone TC, Feng W, Kelly DP, Klein S. Effect of endurance training on lipid metabolism in women: a potential role for PPARalpha in the metabolic response to training. Am J Physiol Endocrinol Metab 2000; 279(2): E348-E355.
  29. Williams M. Nutrition for health, fitness and sport. 6th ed. New York,NY: McGrawHil; 2002.
  30. Gaeeni AA, Kazemi F, BehZaree A. The effects of excessive aerobic continuous and interval training programs on plasma lipoproteins and serum CRP in women. J Kerman Univ Med Sci 2002; 19(3): 277-86. [In Persian].
  31. Lira FS, Yamashita AS, Uchida MC, Zanchi NE, Gualano B, Martins E, et al. Low and moderate, rather than high intensity strength exercise induces benefit regarding plasma lipid profile. Diabetol Metab Syndr 2010; 2: 31.
  32. Askari A, Askari B, Fallah Z, Kazemi Sh. Effect of eight weeks aerobic training on serum lipid and lipoprotein levels in women. J Gorgan Uni Med Sci 2012; 14(1): 26-32. [In Persian].
Journal of Isfahan Medical School
Volume 33, Issue 366 - Serial Number 366
November and December 2016
Pages 2368-2373

Files

History

  • Receive Date: 11 September 2015
  • Revise Date: 23 May 2024
  • Accept Date: 06 April 2022

Share

How to cite

Statistics