Frequency Distribution of Fractures among Hepatitis C Virus (HCV)- or Human Immunodeficiency Virus (HIV)-Positive Patients Referred to Hospital Orthopedic Surgery Wards

Document Type : Original Article (s)

Authors

1 Associate Professor, Department of Orthopedic Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Student of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Some of studies showed that Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV) and related drugs not only have effect on liver and immunity systems but also have effect on musculoskeletal and bone mass density and led to increase of fractures risk; investigations about these effects are limited. The aim of this study was   determining the frequency distribution of fractures among HCV- or HIV-positive patients referred to hospital orthopedic surgery wards.Methods: In a cross-sectional study during 2012-2014, 132 HCV- or HIV-positive patients hospitalized to Kashani and Alzahra hospitals (Isfahan, Iran) due to fractures were studied. Fracture status, improvement time and complications due to fracture were investigated. Findings: Of 132 studied patients, 87 (65.9%) were HCV-positive, 21 (15.9%) HIV-positive, 17 (12.9%) HCV- and HIV-positive and 7 (5.3%) were HCV-positive with cancer. The most prevalent of damage was femur fracture that happened in 69 (52.3%) patients. Kind of damage was related to background diseases and frequency distribution of femur fracture (as the most frequent fracture) in HCV-, HIV-, HCV- and HIV- and HCV-positive with cancer patients was 48.3, 28.6, 88.2 and 85.7 percent, respectively. In addition, the frequency distribution of complications was different based on the kind of background diseases (P = 0.001).    Conclusion: According to the results of this study, prevalence of bone fracture in HCV- or HIV-positive patients was high and probably, was related to lock of bone mass density and increase of bone fracture risk. In addition, post-treatment complications such as infection and un-union were prevalent in these patients. Hence, prevention activities and routine surveillances such as bone densitometry and musculoskeletal surveillance mast be done in these patients.

Keywords

References

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Journal of Isfahan Medical School
Volume 33, Issue 341 - Serial Number 341
May and June 2015
Pages 1057-1065

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History

  • Receive Date: 11 July 2015
  • Revise Date: 23 May 2024
  • Accept Date: 06 April 2022

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