Comparison of the Prevalence of Osteopenia and Osteoporosis in Postmenopausal Women with and without Type 2 Diabetes Mellitus

Document Type : Original Article (s)

Authors

1 Resident, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Assistant Professor, Department of Rheumatology, School of Medicine, Baghiyatallah University of Medical Sciences, Tehran, Iran

3 Associate Professor, Department of Rheumatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

4 Associate Professor, Department of Community Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

5 Assistant Professor, Department of Rheumatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Osteoporosis and diabetes mellitus are major and growing public health problems, particularly among postmenopausal women. This study was conducted to evaluate the relationship between osteoporosis and type 2 diabetes mellitus (DM) in postmenopausal women.Methods: In this cross sectional study, we compared 200 postmenopausal women with type 2 diabetes mellitus and 400 without it, over the age of 60 years. Age, body mass index (BMI), and the T-score of the lumbar vertebra, neck of femur measured via Dual Energy X-ray Absorptiometry (DEXA) were recorded and compared between the two groups. Hemoglobin A1C (HbA1C) was also measured in patients with type 2 diabetes mellitus and its correlation with osteoporosis was studied. Chi-square, Fisher’s exact and independent t tests were used for analyzing the data. In this study, P-value less than 0.05 was considered as significant.Findings: The mean ages were 65.23 ± 4.80 vs. 66.91 ± 5.78 years and BMI were 28.94 ± 4.06 vs. 31.65 ± 4.42 kg/m2 in non-diabetic and diabetic groups, respectively. Lumber T-scores was -2.10 ± 1.08 vs. -2.16 ± 1.27 (P = 0.60), femoral neck T-score was -0.72 ± 1.00 vs. -1.09 ± 0.96 (P < 0.01), in non-diabetic and diabetic groups, respectively. The prevalence of osteopenia and osteoporosis was statistically higher among diabetic group compared to non-diabetics. In diabetic group, osteoporosis was more common in those with HbA1C ≥ 7 compared to those with HbA1C < 7 (P = 0.006).Conclusion: The results of this study showed that bone loss is more common in postmenopausal women ith type 2 diabetes mellitus compared to the postmenopausal women without it. We can control this risk factor, as an important intervention, in the prevention of osteoporosis.

Keywords

References

  1. Bagheri P, Haghdoost AA, Dortaj Rabari E, Halimi L, Vafaei Z, Farhangnia M, et al. Ultra analysis of prevalence of osteoporosis in Iranian women "a systematic review and meta-analysis". Iran J Endocrinol Metab 2011; 13(3): 315-25. [In Persian].
  2. Soheyli Azad AA, Golestan B, Jahanbakhsh S. Determination of the relation between osteoporotic and osteopenic risk factors among women referring to BMD center, Baharloo Hospital. Razi j Med Sci 2008; 14(57): 91-9. [In Persian].
  3. Aghamohammadzadeh N, Najafipour F, Bahrami A, Niafar M, Baglar L, Hajiegrary H, et al. Evaluation of effective factors in decreased bone density in patients with osteoporosis and osteopenia. J Gorgan Uni Med Sci 2009; 11(2): 61-7. [In Persian].
  4. Jamshidian-Tehrani M, Kalantari N, Azadbakht L, Esmaillzadeh A, Rajaie A, Houshiar-rad A. Osteoporosis risk factors in Tehrani women aged 40-60 years. Iran J Endocrinol Metab 2004; 6(2): 139-45. [In Persian].
  5. Abdoli S. Evaluation of usage preventing of osteoporotic behavior in menopausal women. Proceedings of the 1st International Congress of Prevention, Diagnosis, and Treatment of Osteoporosis; 2005 Sep 23-24; Tehran, Iran. p. 116. [In Persian].
  6. Torshizi L, Anoosheh M, Ghofranipour F, Ahmadi F, Houshyar-Rad A. The effect of education based on health belief model on preventive factors of osteoporosis among postmenopausal women. Iran J Nurs 2009; 22(59): 71-82. [In Persian].
  7. Keramat A, Larijani B, Adibi H, Hosseinnejad A, Chopra A, Patwardha B. Risk factors for osteoporosis in urban Iranian postmenopausal women (A center based study). Knowledge Health 2007; 2(3): 36-41. [In Persian].
  8. Larijani B, Soltani A, Pajouhi M, Bastanhagh M, Mirfezi SZ, Dashti R, et al. Bone mineral density variation in 20-69 year population of Tehran/Iran. Iran South Med J 2002; 5(1): 41-9. [In Persian].
  9. Ebrahimof S, Hoseinnejad A, Hoshiar-Rad A, RahmaniM, ValaieN, LarijaniB, et al. Evaluation of association between fruits and vegetables consuming and bone turn over in postmenopausal women. Pejouhandeh 2007; 2(3):159-65. [In Persian].
  10. Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet 2002; 359(9319): 1761-7.
  11. World Health Organization. Prevention and management of osteoporosis. Geneva, Switzerland: WHO; 2003.
  12. Mahdavi-Roshan M, Ebrahimi-Mamghani M, Ebrahimi AA, Ghaem Maghami J. Nutritional and biochemical factors of zinc and calcium in postmenopausal women with osteoporosis in Tabriz-2007. Behbood J 2008; 12(3): 296-307. [In Persian].
  13. Hyun TH, Barrett-Connor E, Milne DB. Zinc intakes and plasma concentrations in men with osteoporosis: the Rancho Bernardo Study. Am J Clin Nutr 2004; 80(3): 715-21.
  14. Scheiber LB, Torregrosa L. Evaluation and treatment of postmenopausal osteoporosis. Semin Arthritis Rheum 1998; 27(4): 245-61.
  15. Leslie M, St Pierre RW. Osteoporosis: implications for risk reduction in the college setting. J Am Coll Health 1999; 48(2): 67-71.
  16. Bayat N, Haji Amini Z, Alishiri Gh, Ebadi A, Hosseini M, Laluee A. Frequency of osteoporosis and osteopenia in post menopausal military family's women. J Army Univ Med Sci I R Iran 2008; 6(1): 25-30. [In Persian].
  17. Schwartz AV, Sellmeyer DE, Ensrud KE, Cauley JA, Tabor HK, Schreiner PJ, et al. Older women with diabetes have an increased risk of fracture: a prospective study. J Clin Endocrinol Metab 2001; 86(1): 32-8.
  18. Thorpe SR, Baynes JW. Maillard reaction products in tissue proteins: new products and new perspectives. Amino Acids 2003; 25(3-4): 275-81.
  19. Yao D, Taguchi T, Matsumura T, Pestell R, Edelstein D, Giardino I, et al. High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A. J Biol Chem 2007; 282(42): 31038-45.
  20. Paula FJ, Rosen CJ. Obesity, diabetes mellitus and last but not least, osteoporosis. Arq Bras Endocrinol Metabol 2010; 54(2): 150-7.
  21. Yamamoto M, Yamaguchi T, Yamauchi M, Yano S, Sugimoto T. Serum pentosidine levels are positively associated with the presence of vertebral fractures in postmenopausal women with type 2 diabetes. J Clin Endocrinol Metab 2008; 93(3): 1013-9.
  22. Moghimi N, Rahimi E ,Derakhshan S, Farhadifar F. Osteoporosis in postmenopausal diabetic women; prevalence and related factors. Iran J Nucl Med 2008; 16(2): 28-33.
  23. Bahrami A. The relationship between body mass index and prevalence rate of osteopenia and osteoporosis in a urban population. Proceedings of the 1st International Congress of Prevention, Diagnosis, and Treatment of Osteoporosis; 2005 Sep 23-24; Tehran. Iran. p. 31-2. [In Persian].
  24. Hosein Nejad A, Larijani B, Pajouhi M, Adibi H, Maghboli Zh. Association between type 2 of diabete mellitus and lifestyle with osteoporosis pre- and postmenopausal women. Iran J Endocrin Methabol 2004: 3(1): 47-52. [In Persian].
  25. Christensen JO, Svendsen OL. Bone mineral in pre- and postmenopausal women with insulin-dependent and non-insulin-dependent diabetes mellitus. Osteoporos Int 1999; 10(4): 307-11.
Journal of Isfahan Medical School
Volume 32, Issue 289 - Serial Number 289
May and June 2014
Pages 889-900

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History

  • Receive Date: 21 April 2012
  • Revise Date:
  • Accept Date: 06 April 2022

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