Investigation of the Protective Effects of Myo-inositol on Cisplatin-Induced Nephrotoxicity in Rats

Document Type : Original Article(s)

Authors

1 Assistant Professor, Department of Basic Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran

2 Associate Professor, Department of Pathobiology, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran

3 Graduated in Veterinary Medicine, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran

10.48305/jims.v43.i830.1088

Abstract

Background: Despite the widespread use and success of cisplatin in treating various tumors, this chemotherapeutic drug often causes nephrotoxicity in many patients. Given the high antioxidant capacity of inositol, this study aimed to investigate the effects of this nutritional supplement on cisplatin-induced nephrotoxicity in rats.
Methods: Twenty-four adult female Wistar rats were randomly divided into four equal groups (n = 6) and treated orally for 21 days as follows: negative control (normal saline), positive control (normal saline), comparative control (vitamin C), and the treatment group (myoinositol). All groups, except for the negative control, received intraperitoneal cisplatin on day 15. On day 22, blood samples were collected from anesthetized animals. Subsequently, they were euthanized by deepening the anesthesia, and their kidneys were harvested for histopathological and histomorphometric analysis, as well as biochemical tests.
Findings: Pretreatment with myoinositol improved histopathological lesions and reduced elevated urea and creatinine levels caused by cisplatin. Additionally, myoinositol alleviated oxidative stress by increasing reduced glutathione, glutathione peroxidase, and total antioxidant capacity in kidney tissue.
Conclusion: The results of this study demonstrated that pretreatment with myoinositol, similar to vitamin C, significantly protected against nephrotoxicity induced by cisplatin, which can be attributed to its antioxidant properties.

Highlights

Fatemeh Hoseinpour: Google Scholar

Mohammad Hashemnia: Google Scholar

Keywords

Main Subjects

References

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Journal of Isfahan Medical School
Volume 43, Issue 830
2nd Week, November
November and December 2025
Pages 1088-1098

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History

  • Receive Date: 07 February 2025
  • Accept Date: 13 September 2025

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