Clinical and Serological Predicting Factors for Dialysis in Infants and Children with Hemolytic Uremic Syndrome Referred to Qazvin Children's Hospital in 2020-2021

Document Type : Original Article(s)

Authors

1 Clinical Research Development Unit, Booalisina Hospital, Qazvin University of Medical Sciences, Qazvin, Iran

2 Assistant Professor, Children Growth Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran

3 Associate Professor, Clinical Research Development Unit of Advanced Medicine, Qazvin University of Medical Sciences, Qazvin, Iran

4 Assistant Professor, Pediatric Nephrology Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract

Background: Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy characterized by thrombocytopenia, microangiopathic hemolytic anemia, and acute renal failure. The purpose of this research is to determine the clinical and laboratory factors predicting the need for dialysis in infants and children with hemolytic uremic syndrome.
Methods: The present analytical cross-sectional study was conducted on children aged 6 months to 13 years with HUS admitted to the Qazvin Children's Hospital in 2020 and 2021. Demographic information and clinical and laboratory findings were recorded. The clinical and laboratory factors of the children who underwent dialysis were statistically compared with those who did not indicate dialysis.
Findings: In a comparison of demographic, clinical, and laboratory indicators in dialysis and non-dialysis patients, mean urine volume, hematocrit level, BUN (Blood urea Nitrogen), creatinine, and GFR (Glomerular filtration rate) were statistically different between the two groups (P < 0.05).
Conclusion: Based on the findings, urine output, hematocrit level, BUN, creatinine, and GFR on the first day and during hospitalization can predict dialysis requirements in HUS patients.

Highlights

Reza Dalirani: Google Scholar, PubMed

Banafsheh Arad: Google Scholar, PubMed 

Keywords

Main Subjects

References

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Journal of Isfahan Medical School
Volume 42, Issue 768
4th Week, July
July and August 2024
Pages 404-410

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History

  • Receive Date: 03 November 2023
  • Accept Date: 11 August 2024

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