تحلیل آماری میزان خستگی مزمن در مبتلایان به کووید-19 شهر اصفهان

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 دانشجو، گروه پزشکی اجتماعی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

2 استادیار، گروه پزشکی اجتماعی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

3 استاد، گروه آمار، دانشکده‌ی ریاضی و آمار، دانشگاه اصفهان، اصفهان، ایران

10.48305/jims.v43.i832.1173

چکیده

مقاله پژوهشی




مقدمه: پژوهش حاضر با هدف تعیین ارتباط بین ابتلا به کووید-19 و سندرم خستگی مزمن انجام شد.
روش‌ها: این مطالعه‌ی مقطعی و توصیفی- تحلیلی بر روی افراد 18 تا 60 سال بدون سابقه‌ی بیماری زمینه‌ای که طی 6 تا 12 ماه گذشته به کرونا مبتلا شده و به‌صورت سرپایی برای انجام تست PCR به مراکز منتخب کرونا در اصفهان مراجعه کرده بودند، انجام شد. معیارهای ورود شامل تأیید ابتلا با تست PCR و رضایت شرکت‌کنندگان بود. افراد با سابقه بستری یا بیماری‌های زمینه‌ای جسمی و روانی از مطالعه حذف شدند. 386 نمونه به روش تصادفی ساده از فهرست 2863 نفری سامانه جامع داده‌های کرونا مرکز منتخب انتخاب شد. برای سنجش خستگی از پرسشنامه چالدر با آلفای کرونباخ 0/91 استفاده شد که روایی و پایایی آن توسط فلاح و تقی‌زاده در ایران تأیید شده است.
یافته‌ها: میانگین خستگی بیماران 29/72 (در محدوده‌ی نمره 14تا70) می‌باشد که کمتر از مقدار متوسط 42 است. بین میزان خستگی زنان و مردان و همچنین بین میانگین میزان خستگی با سن و شاخص توده‌ی بدنی تفاوت معنی‌داری وجود نداشت. اما با افرایش سن، میانگین خستگی اندکی کاهش یافت. میانگین خستگی برای افراد با شاخص توده‌ی بدنی نرمال، کمی پایین‌تر از افراد با شاخص توده‌ی بدنی غیر نرمال بود. میانگین خستگی در مشاغل کم‌تحرک مانند دانشجو، بازنشسته و خانه‌دار بیشتر از کادر بیمارستان، کارمند و کارگر بود.
نتیجه‌گیری: بر اساس نتایج به نظر می‌رسد، میزان خستگی مزمن 6 تا 12 ماه پس از ابتلا به کرونا در افرادی که به‌صورت سرپایی جهت انجام تست PCR مراجعه کرده بودند به طور کلی کم یا بسیار کم است.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Statistical Analysis of Chronic Fatigue in COVID-19 Patients in the City of Isfahan

نویسندگان [English]

  • Zeynab Javadi Sebdani 1
  • Sayed Reza Eshaghi 2
  • Nasrollah Iranpanah 3
1 Student, Department of Social Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Assistant Professor, Department of Community Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Professor, Department of Statistics, Faculty of Mathematics and Statistics, University of Isfahan, Isfahan, Iran
چکیده [English]

Background: This study aimed to determine the relationship between COVID-19 infection and chronic fatigue syndrome.
Methods: A cross-sectional, descriptive-analytical study was conducted on individuals aged 18 to 60 without underlying medical conditions who had contracted COVID-19 within the past 6 to 12 months and had visited selected COVID-19 centers in Isfahan for outpatient PCR testing. Inclusion criteria were PCR-confirmed infection and participant consent, while those with a history of hospitalization or physical/mental comorbidities were excluded. A sample of 386 participants was randomly selected from a list of 2,863 in the comprehensive COVID-19 database. Fatigue was assessed using the Chalder Fatigue Questionnaire, which had a Cronbach's alpha of 0.91, validated by Fallah and Taghizadeh in Iran.
Findings: The average fatigue score among patients was 29.72 (ranging from 14 to 70), which is lower than the midpoint threshold of 42. There was no significant difference in fatigue levels between males and females, nor in average fatigue levels with age and BMI. However, with increasing age, the mean fatigue score decreased slightly. The mean fatigue score for individuals with a normal BMI was slightly lower than for those with an abnormal BMI. Fatigue levels were higher in less active occupations such as students, retirees, and homemakers compared to hospital staff, office workers, and laborers.
Conclusion: The results suggest that chronic fatigue levels 6 to 12 months post-COVID-19 infection in individuals who had outpatient PCR testing are generally low or very low.

کلیدواژه‌ها [English]

  • Chronic Fatigue Syndrome
  • COVID-19
  • Coronavirus
  1. Sadeghi F, Abolghasemi A, Kazemi R, Narimani M. The effectiveness of positive cognitive-behavioral therapy on orientation of life in female teachers with chronic fatigue syndrome [in Persian]. Journal of Clinical Psychology 2019; 11(2): 23-31.
  2. Deumer U-S, Varesi A, Floris V, Savioli G, Mantovani E, López-Carrasco P, et al. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): an overview. J Clin Med 2021; 10(20): 4786.
  3. Bhatti AB, ul Haq A. The pathophysiology of perceived social isolation: effects on health and mortality. Cureus 2017; 9(1): e994.
  4. Brooks SK, Webster RK, Smith LE, Woodland L, Wessely S, Greenberg N, et al. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet 2020; 395(10227): 912-20.
  5. Facmhn kuarp, Bhullar N. Life in the pandemic: Social isolation and mental health. J Clin Nurs 2020; 29(15-16): 2756-7.
  6. Shaver K. ‘Quarantine fatigue’: researchers find more Americans venturing out against coronavirus stay-at-home orders. Washington Post 2020.
  7. Zhang L, Darzi A, Ghader S, Pack ML, Xiong C, Yang M, et al. Interactive COVID-19 mobility impact and social distancing analysis platform. Transp Res Rec 2021; 2677(4): 168-80.
  8. Zhao J, Lee M, Ghader S, Younes H, Darzi A, Xiong C, Zhang L. Quarantine fatigue: first-ever decrease in social distancing measures after the COVID-19 pandemic outbreak before reopening United States. arXiv preprint. 2020: PPR346915.
  9. Cortes Rivera M, Mastronardi C, Silva-Aldana CT, Arcos-Burgos M, Lidbury BA. Myalgic encephalomyelitis/chronic fatigue syndrome: a comprehensive review. Diagnostics (Basel) 2019; 9(3): 91.
  10. Daniels J, Parker H, Salkovskis PM. Prevalence and treatment of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and co-morbid severe health anxiety. Int J Clin Health Psychol 2020; 20(1): 10-9.
  11. Encephalomyelitis BM. Redefining an Illness. Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; Board on the Health of Select Populations; Institute of Medicine: Washington (DC): National Academies Press (US); 2015.
  12. Rahimian-Boogar I, Rezaei AM. The Quality of Life in Patients with Chronic Fatigue Syndrome: Predictive Role of Psychological and Demographical Factor [in Persian]. Journal of Clinical Psychology 2012; 4(3): 43-52.
  13. Bogovič P, Lusa L, Korva M, Lotrič-Furlan S, Resman-Rus K, Pavletič M, et al. Inflammatory immune responses in patients with tick-borne encephalitis: dynamics and association with the outcome of the disease. Microorganisms 2019; 7(11): 514.
  14. Del Rio C, Malani PN. COVID-19—new insights on a rapidly changing epidemic. JAMA 2020; 323(14): 1339-40.
  15. Garcia MN, Hause AM, Walker CM, Orange JS, Hasbun R, Murray KO. Evaluation of prolonged fatigue post–West Nile virus infection and association of fatigue with elevated antiviral and proinflammatory cytokines. Viral Immunol 2014; 27(7): 327-33.
  16. Islam MF, Cotler J, Jason LA. Post-viral fatigue and COVID-19: lessons from past epidemics. Fatigue: Biomedicine, Health & Behavior 2020; 8(2): 61-9.
  17. Jason LA, Katz BZ, Shiraishi Y, Mears CJ, Im Y, Taylor RR. Predictors of post-infectious chronic fatigue syndrome in adolescents. Health Psychol Behav Med 2014; 2(1): 41-51.
  18. Lam MH-B, Wing Y-K, Yu MW-M, Leung C-M, Ma RC, Kong AP, et al. Mental morbidities and chronic fatigue in severe acute respiratory syndrome survivors: long-term follow-up. Arch Intern Med 2009; 169(22): 2142-7.
  19. Mantovani E, Mariotto S, Gabbiani D, Dorelli G, Bozzetti S, Federico A, et al. Chronic fatigue syndrome: an emerging sequela in COVID-19 survivors? J Neurovirol 2021; 27(4): 631-7.
  20. Moldofsky H, Patcai J. Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study. BMC Neurol 2011; 11: 37.
  21. Radusin M. The Spanish flu, part II: The second and third wave. Vojnosanit Pregl 2012; 69(10): 917-27.
  22. Wilson HW, Amo-Addae M, Kenu E, Ilesanmi OS, Ameme DK, Sackey SO. Post-Ebola syndrome among Ebola virus disease survivors in Montserrado County, Liberia 2016. Biomed Res Int 2018; 2018(1): 1909410.
  23. Agergaard J, Leth S, Pedersen T, Harbo T, Blicher J, Karlsson P, et al. Myopathic changes in patients with long-term fatigue after COVID-19. Clin Neurophysiol 2021; 132(8): 1974-81.
  24. Ahmed MU, Hanif M, Ali MJ, Haider MA, Kherani D, Memon GM, et al. Neurological manifestations of COVID-19 (SARS-CoV-2): a review. Front Neurol 2020; 11: 518.
  25. Ellul MA, Benjamin L, Singh B, Lant S, Michael BD, Easton A, et al. Neurological associations of COVID-19. Lancet Neurol 2020; 19(9): 767-83.
  26. World Health Organization. Coronavirus Disease (COVID-19) Situation Report 121, Data as Received by WHO from National Authorities by 10: 00 CEST. [20 May 2020] 2020. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200520-covid-19-sitrep-121.pdf
  27. Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun 2020; 109: 102433.
  28. Varatharaj A, Thomas N, Ellul MA, Davies NW, Pollak TA, Tenorio EL, et al. Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study. Lancet Psychiatry 2020; 7(10): 875-82.
  29. Werion A, Belkhir L, Perrot M, Schmit G, Aydin S, Chen Z, et al. SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule. Kidney Int 2020; 98(5): 1296-307.
  30. Fallah S, Taghizadeh G, Parnain Z, Cheraghifard M, Taghavi Azar Sharabiani P, Yousefi M, et al. Persian version of the Chalder Fatigue Questionnaire and Multidimensional Fatigue Symptom Inventory-Short Form: psychometric properties in Iranian chronic stroke survivors. Top Stroke Rehabil 2023; 30(8): 796--806.
  31. González-Hermosillo JA, Martínez-López JP, Carrillo-Lampón SA, Ruiz-Ojeda D, Herrera-Ramírez S, Amezcua-Guerra LM, Martínez-Alvarado MdR. Post-acute COVID-19 symptoms, a potential link with myalgic encephalomyelitis/chronic fatigue syndrome: a 6-month survey in a Mexican cohort. Brain Sci 2021; 11(6): 760.
  32. Liu H. Fatigue and associated factors in hemodialysis patients in Taiwan. Res Nurs Health 2006; 29(1): 40-50.
  33. Mollaoglu M. Fatigue in people undergoing hemodialysis. Dialysis & Transplantation 2009; 38(6): 216-20.
  34. O'Sullivan D, McCarthy G. An exploration of the relationship between fatigue and physical functioning in patients with end stage renal disease receiving haemodialysis. J Clin Nurs 2007; 16(11c): 276-84.
  35. Song H-J, Kim H-J. Fatigue associated with kidney disease symptoms in female patients undergoing hemodialysis. Journal of Korean Academy of Fundamentals of Nursing 2007; 14(4): 474.