دوره 36، شماره 500: هفته چهارم آذر ماه 1397:1248-1260

دریافت اسید فولیک و خطر سرطان پستان: مقاله‌ی مروری

حدیث سوری‌نژاد , الهام ادیب مقدم , زمزم پاک‌نهاد

DOI: 10.22122/jims.v36i500.10412

چکیده


مقدمه: سرطان پستان، شایع‌ترین سرطان تهاجمی در زنان و نیز شایع‌ترین دلیل مرگ ناشی از سرطان است و 2/25 درصد از تمام سرطان‌های تازه تشخیص داده شده در سراسر جهان را شامل می‌شود. این بیماری، چند عاملی است و علاوه بر وضعیت محیطی و ارثی، وضعیت تغذیه و عوامل غذایی از جمله فولات، ویتامین‌‌های B6 و B12 و الکل نیز ممکن است با آن مرتبط باشند.

روش‌ها: در این مطالعه، با استفاده از موتورهای جستجو شامل PubMed، Proquest، Scopus، Science direct و Web of Science، بر اساس کلید واژه‌های Breast cancer، Breast Neoplasms، Folic acid و Vitamin B9، مطالعات مورد- شاهدی (13 مطالعه)، هم‌گروهی (10 مطالعه) و 1 مطالعه‌ی Case series طی سال‌های 2018-2007 مورد بررسی قرار گرفت.

یافته‌ها: با بررسی مطالعات انجام شده، به نظر می‌رسد که رژیم غذایی غنی از فولات، با کاهش خطر ابتلا به سرطان پستان همراه نیست. اثر حفاظتی فولات بر سرطان پستان متناقض است و احتمال می‌رود مصرف فولات منجر به پیش‌گیری از سرطان پستان در سنین قبل از یائسگی شود و به طور عمده بر روی نوع گیرنده‌ی منفی این تأثیر را اعمال خواهد کرد. با این وجود، تفاوت در حجم نمونه، منطقه‌ی انجام مطالعه، طراحی مطالعه و روش‌های ارزیابی، ممکن است باعث ناهم‌گونی در نتایج مطالعات شده باشد.

نتیجه‌گیری: ارتباط بین فولات و سرطان پستان همواره مبهم بوده است و نیازمند مطالعات بیشتر و در نظر گرفتن وضعیت یائسگی و گیرنده‌ی هورمونی است تا به نتایج شفاف‌تری در این زمینه دست یابیم.


واژگان کلیدی


سرطان پستان؛ نئوپلاسم پستان؛ اسید فولیک؛ ویتامین B9

تمام متن:

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