نوع مقاله : مقاله مروری
نویسندگان
1 گروه هماتولوژی و بانک خون، دانشکده پیراپزشکی، دانشگاه علوم پزشکی ایران، تهران، ایران
2 واحد طراحی دارو و بیوانفورماتیک، گروه بیوتکنولوژی پزشکی، مرکز تحقیقات بیوتکنولوژی، انستیتو پاستور ایران، تهران، ایران
3 مرکز تحقیقات علوم و فناوری آزمایشگاهی تشخیصی، دانشکده پیراپزشکی، دانشگاه علوم پزشکی شیراز، شیراز، ایران
4 گروه تصویربرداری ملکولی، دانشکده فناوری های نوین پزشکی، دانشگاه علوم پزشکی ایران، تهران، ایران
چکیده
تازه های تحقیق
سیما کلانتری: Google Scholar
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Introduction: Platelets are multi-purpose cell parts circulating abundantly in the blood and can be educated by their environment. Platelets actively change their nucleic acid content in response to local and systemic pathological conditions and can play a role in cancer development and progression by supporting the growth, survival and dissemination of tumor cells. In the current study, the importance of RNAs in platelets -as less invasive biomarkers- for early diagnosis of cancers and also for tracking tumor progression has been investigated. Methods: For this review study the reliable scientific databases such as PubMed, Web of science, Scopus, and Google scholar has been used to collect related articles. Findings: The nucleic acid content of platelets is provided both by their generator (megakaryocyte) and mediators such as cancer cells. Different types of coding and non-coding RNA make up the nucleic acid content of platelets, and cancer cells affect platelet RNA content in tumor-educated platelets (TEP) through direct and indirect pathways. Discussion: Advances in molecular technologies and subsequent deep insight into the profile of TEP RNAs, including the discovery of small and longer regulatory RNAs, have enabled the analysis of TEP RNA profiles as a new source for early cancer diagnosis.
کلیدواژه‌ها [English]
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