اهمیت انواع ملکول‌های RNA موجود در پلاکت‌ها جهت تشخیص و نظارت بر پیشرفت تومور

نوع مقاله : مقاله مروری

نویسندگان

1 کارشناسی ارشد، گروه هماتولوژی و بانک خون، دانشکده‌ی پیراپزشکی، دانشگاه علوم پزشکی ایران، تهران، ایران

2 دانشجوی دکتری، واحد طراحی دارو و بیوانفورماتیک، گروه بیوتکنولوژی پزشکی، مرکز تحقیقات بیوتکنولوژی، انستیتو پاستور ایران، تهران، ایران

3 کارشناسی ارشد، مرکز تحقیقات علوم و فناوری آزمایشگاهی تشخیصی، دانشکده‌ی پیراپزشکی، دانشگاه علوم پزشکی شیراز، شیراز، ایران

4 دکترای تخصصی، گروه تصویربرداری مولکولی، دانشکده‌ی فناوری‌های نوین پزشکی، دانشگاه علوم پزشکی ایران، و گروه پزشکی بازساختی (REMED)، شبکه‌ی جهانی آموزش و تحقیقات علمی (USERN)، تهران، ایران

چکیده

مقاله مروری




مقدمه: پلاکت‌ها، قطعات سلولی چند منظوره هستند که به وفور در خون گردش می‌کنند و می‌توانند توسط محیط خود آموزش ببینند. پلاکت‌ها به طور فعال محتوای اسید نوکلئیک خود را در پاسخ به شرایط پاتولوژیک موضعی و سیستمیک تغییر می‌دهند و می‌توانند از طریق حمایت از رشد، بقا و انتشار سلول‌های تومور در توسعه و پیشرفت سرطان نقش داشته باشند. در مطالعه‌ی حاضر، اهمیت RNAs موجود در پلاکت‌ها به عنوان نشانگرهای زیستی کمتر تهاجمی جهت تشخیص زودهنگام سرطان‌ها و همچنین پیگیری پیشرفت تومور، مورد بررسی قرار گرفته است.
روش‌ها: این مطالعه از نوع مروری بوده و برای جمع‌آوری مقالات مرتبط از پایگاه‌های معتبر علمی نظیرPubMed ، Web of Science، Scopus و Google Scholar استفاده شده است.
یافته‌ها: محتوای اسید نوکلئیک پلاکت‌ها هم توسط مولد آن‌ها (مگاکاریوسیت) و هم واسطه‌هایی مانند سلول‌های توموری فراهم می‌شود. انواع مختلف RNA کدکننده و غیر کدکننده محتوای اسید نوکلئیک پلاکت‌ها را تشکیل می‌دهند و سلول‌های توموری از مسیرهای مستقیم و غیرمستقیم بر محتوای RNA پلاکتی در پلاکت‌های آموزش دیده با تومور (Tumor-educated platelets) TEP تأثیر می‌گذارند.
نتیجه‌گیری: با پیشرفت در فناوری‌های مولکولی و در نتیجه بینش عمیق در مورد مشخصات TEP RNAs، از جمله کشف RNAs تنظیم‌کننده کوچک و طولانی‌تر، امکان تجزیه و تحلیل پروفایل TEP RNA به عنوان منبع جدیدی برای تشخیص زودهنگام سرطان فراهم شده است.

تازه های تحقیق

سیما کلانتری: Google Scholar

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The Importance of Different Types of RNA Molecules in Platelets for the Diagnosis and Monitoring of Tumor Progression

نویسندگان [English]

  • Abolfazl Kalantari 1
  • Afsaneh Tavasoli 2
  • Golnaz Minaeian 3
  • Sima Kalantari 4
1 MSc, Department of Hematology and Blood Banking, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
2 PhD Student, Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
3 MSc, Diagnostic Laboratory Science and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
4 PhD, Department of Molecular Imaging, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, AND Regenerative Medicine Group (REMED), Universal Scientific Education & Research Network (USERN), Tehran, Iran
چکیده [English]

Background: Platelets are multi-purpose cell parts circulating abundantly in the blood and can be educated by their environment. Platelets actively change their nucleic acid content in response to local and systemic pathological conditions and can play a role in cancer development and progression by supporting the growth, survival, and dissemination of tumor cells. In the current study, the importance of RNAs in platelets -as less invasive biomarkers- for early diagnosis of cancers and also for tracking tumor progression has been investigated.
Methods: Reliable scientific databases such as PubMed, Web of Science, Scopus, and Google Scholar were used to gather relevant articles for this review study.
Findings: The nucleic acid content of platelets is provided both by their generator (megakaryocyte) and mediators such as cancer cells. Different types of coding and non-coding RNA make up the nucleic acid content of platelets, and cancer cells affect platelet RNA content in tumor-educated platelets through direct and indirect pathways.
Conclusion: Advances in molecular technologies and subsequent deep insight into the profile of tumor-educated platelet RNAs, including the discovery of small and longer regulatory RNAs, have enabled the analysis of tumor-educated platelet RNA profiles as a new source for early cancer diagnosis.

کلیدواژه‌ها [English]

  • Tumor biomarkers
  • Blood platelets
  • RNA
  • Tumor-educated platelet

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مجله دانشکده پزشکی اصفهان
دوره 42، شماره 753
هفته 1، فروردین
فروردین و اردیبهشت 1403
صفحه 15-28

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  • تاریخ دریافت: 24 مهر 1402
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