نوع مقاله : مقاله کوتاه
نویسندگان
1 دانشجوی کارشناسی ارشد، گروه فیزیولوژی ورزشی، دانشکدهی تربیت بدنی، دانشگاه شهید چمران اهواز، اهواز، ایران
2 دانشیار، مرکز تحقیقات توانبخشی عصبی عضلانی و گروه نورولوژی، دانشگاه علوم پزشکی جندی شاپور، اهواز، ایران
3 استادیار، گروه فیزیولوژی ورزشی، دانشکدهی تربیت بدنی، دانشگاه شهید چمران اهواز، اهواز، ایران
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
Background: Multiple sclerosis (MS) is a demyelinating autoimmune disease, with an unclear mechanism, and characterized by axonal damage, demyelination and increase inflammatory. Recently, it has been found that leptin plays a role in the pathogenesis of multiple sclerosis. The current study aimed to compare serum level of leptin and aerobic capacity in relapsing and remitting duration in women with multiple sclerosis.Methods: 32 women with multiple sclerosis including 12 in relapsing and 20 in remitting phases participated in this study. Serum level of leptin was assessed using enzyme-linked immunosorbent assay (ELISA) kit and aerobic capacity was measured using ergometer cycle incremental test. Independent t and Pearson correlation tests were used for data analysis at the significant level of P ≤ 0.05.Findings: Data indicated that leptin was higher in relapsing group; but, aerobic capacity was higher in remitting group (P ≤ 0.05). In addition, a negative and significant correlation was observed between leptin and aerobic capacity in both groups and leptin and body mass index in remitting group (P ≤ 0.05).Conclusion: According to the result, increasing of leptin and decreasing of aerobic capacity associated with relapsing in patients with relapsing-remitting multiple sclerosis.
کلیدواژهها [English]