دوره 37، شماره 520: هفته چهارم اردیبهشت ماه 1398:278-287

مروری کلی بر مسیرهای تنظیمی احساس اکسیژن محیطی و ریزمحیطی توسط عوامل القا شده به ‌وسیله‌ی هیپوکسی (HIF)

فاطمه چوپانی , علی چوپانی , محمود تولایی , نسرین کریمی‌نژاد, حوری عدالت

DOI: 10.22122/jims.v37i520.11114

چکیده


کمبود اکسیژن یا هیپوکسی، می‌تواند کمبود اکسیژن محیط بیرون از بدن (حس شده توسط سلول‌های ریوی) یا کمبود اکسیژن ریزمحیط‌های درونی بدن (حس شده توسط سایر سلول‌های بدن همچون سلول‌های سرطانی) را شامل گردد. پاسخ سلولی به نوسانات اکسیژن به ‌طور عمده توسط عوامل القا شده به ‌وسیله‌ی هیپوکسی (Hypoxia-inducible factors یا HIFs) میانجی‌گری می‌شوند. به طور کلی، اولین اندام که بعد از هر دم که باعث دمیدن اکسیژن محیط به داخل و تماس با آن می‌شود، ریه می‌باشد. با این وجود، هنوز مسیرهای تنفسی شناخته‌ شده‌ی Hif برای احساس اکسیژن محیطی در ریه بسیار محدود است. از این رو، در این مقاله‌ی مروری، ابتدا نقش ایزوفرم‌های HIF1 و HIF2 در عروق و برونش‌های ریوی (مشتمل بر سلول‌های عضله‌ی صاف و اندوتلیال عروق و سلول‌های اپی‌تلیال برونشیال ریوی) و پاسخ‌های آن به ناکافی بودن اکسیژن محیطی مورد بررسی قرار می‌گیرد. سپس، به بررسی نقش HIF در احساس اکسیژن ریزمحیطی (داخلی) در سلول‌ها و بافت‌های غیر ریوی همراه با کلیه‌ی مکانیزم‌های مولکولی درگیر در آن سلول و بافت‌ها پرداخته می‌شود. آن گاه، از بین کلیه‌ی سلول‌های درگیر در مسیرهای احساس اکسیژن ریزمحیطی، به طور ویژه‌ای به تومورها و سلول‌های سرطانی و سلول‌های بنیادی سرطانی و نقش دقیق‌تر مولکول HIF در این سلول‌ها و بافت‌ها اشاره می‌گردد.


واژگان کلیدی


هیپوکسی؛ HIFs؛ ریه؛ سرطان

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