بررسی اثر مصرف رژیم غذایی با محدودیت متوسط کربوهیدرات بر عوامل خطر بیماری‌های قلبی- عروقی در زنان مبتلا به سندرم متابولیک

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 دانشجوی کارشناسی ارشد، گروه تغذیه‌ی جامعه، دانشکده‌ی تغذیه و علوم غذایی، مرکز تحقیقات امنیت غذایی و کمیته‌ی تحقیقات دانشجویی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

2 دانشیار، مرکز تحقیقات امنیت غذایی و گروه تغذیه‌ی جامعه، دانشکده‌ی تغذیه و علوم غذایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

3 دانشیار، گروه فیزیولوژی، دانشکدهی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

مقدمه: افزایش اپیدمی‌ چاقی و سندرم متابولیک با کاهش میزان دریافت چربی و افزایش کربوهیدرات رژیم غذایی همراه بوده است. مطالعه‌ی حاضر با هدف بررسی اثر جایگزینی متوسط کربوهیدرات رژیم غذایی با چربی‌ها بر سندرم متابولیک صورت پذیرفت.روش‌ها: این مطالعه به روش کارآزمایی بالینی متقاطع بر روی 30 زن دارای اضافه وزن یا چاقی (شاخص توده‌ی بدنی بالای 25 کیلوگرم بر مترمربع) مبتلا به سندرم متابولیک انجام شد. شرکت کنندگان به طور تصادفی به دو گروه رژیم غذایی پرکربوهیدرات (65-60 درصد کربوهیدرات، 25-20 درصد چربی) و رژیم غذایی با محدودیت متوسط کربوهیدرات (47-43 درصد کربوهیدرات، 40-36 درصد چربی) تخصیص یافتند. هر مرحله‌ی مداخله 6 هفته و دوره‌ی Washout دو هفته به طول انجامید. در شروع و پایان هر مرحله فشارخون، شاخص‌های تن‌سنجی و بیوشیمیایی ارزیابی گردید.یافته‌ها: با وجود کاهش وزن مشابه، دور کمر (9/3- در مقابل 6/2- سانتی‌متر؛ 07/0 = P) و دور باسن (7/2- در مقابل 5/1- سانتی‌متر؛ 07/0 = P) طی رژیم غذایی با محدودیت متوسط کربوهیدرات بیش از رژیم پرکربوهیدرات کاهش یافت. بر خلاف رژیم غذایی پرکربوهیدرات، رژیم با محدودیت متوسط کربوهیدرات موجب تغییرات مطلوب در سطح تری‌گلیسرید (TG) (13/0 در مقابل 3/13- میلی‌گرم در دسی‌لیتر؛ 07/0 = P) و نسبت تری‌گلیسرید به HDL-C (High density lipoprotein-cholesterol) (1/0 در مقابل 9/0، 06/0=P) سرم شد. محدودیت متوسط کربوهیدرات رژیم غذایی در مقایسه با رژیم پرکربوهیدرات کاهش بیشتری در فشارخون سیستولیک (93/8- در مقابل 97/2- میلی‌متر جیوه؛ 06/0 = P) و دیاستولیک (7/12- در مقابل 77/1- میلی‌متر جیوه؛ 001/0 > P) ایجاد نمود. شیوع سندرم متابولیک تنها پیرو رژیم غذایی با محدودیت متوسط کربوهیدرات، به طور معنی‌داری کاهش یافت (03/0 > P).نتیجه‌گیری: شایسته است جایگزینی متوسط کربوهیدرات رژیم غذایی با چربی‌های غیراشباع، به عنوان راهکاری مؤثر جهت پیش‌گیری و درمان سندرم متابولیک توصیه گردد.

کلیدواژه‌ها

عنوان مقاله [English]

Effects of a Moderately-Restricted Carbohydrate Diet on Cardiovascular Risk Factors among Women with Metabolic Syndrome

نویسندگان [English]

  • Somayeh Rajaie 1
  • Leila Azadbakht 2
  • Majid Khazaei 3
  • Ahmad Esmaillzadeh 2
1 MSc Student, Department of Community Nutrition, School of Nutrition and Food Sciences and Food Security Research Center And Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
2 Associate Professor, Food Sciences and Food Security Research Center and Department of Community Nutrition, School of Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran
3 Associate Professor, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

Background: The growing epidemics of obesity and metabolic syndrome (MetS) have been accompanied with dietary fat restriction and carbohydrate elevation. We evaluated the efficacy of moderately-restricted carbohydrate diet on features of the MetS in women.Methods: In a randomized cross-over clinical trial, 30 overweight or obese (Body mass index > 25 kg/m2) women with the MetS were enrolled. Subjects were randomly allocated to receive either a high-carbohydrate (HC) (60-65% carbohydrates, 20-25% fats) or a moderately-restricted carbohydrate (MRC) (43-47% carbohydrate, 36-40% fats) diet. Diets were continued for 6 weeks followed by a 2-week washout period. Anthropometrics, blood pressure and biochemical variables were measured before and after each intervention period.Findings: Despite similar weight loss in both diets, the efficacy of MRC diet in reducing waist (-3.9 vs. -2.6 cm; P = 0.07) and hip circumferences (-2.7 vs. -1.5 cm; P = 0.07) was marginally greater compared with HC diet. In contrast to HC diet, MRC diet resulted in favorable changes in serum triglyceride (TG) concentrations (0.13 vs. -31.3 mg/dL; P = 0.07). This was also the case for TG to high density lipoprotein (HDL)-cholesterol ratio (-0.9 vs. -0.1; P = 0.06). The reductions in systolic blood pressure (-8.93 vs. -2.97 mmHg; P = 0.06) and diastolic blood pressure (-12.7 vs. -1.77 mmHg; P = 0.001) by MRC diet were higher than those by HC diet. The prevalence of MetS was significantly decreased only by MRC diet (P = 0.03). Conclusion: Partial replacement of dietary carbohydrates by unsaturated fats might be recommended as an effective strategy for treatment of MetS.

کلیدواژه‌ها [English]

  • Moderate carbohydrate restriction
  • Macronutrient
  • Metabolic Syndrome
  • Blood Pressure
  • Obesity

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مجله دانشکده پزشکی اصفهان
دوره 29، شماره 171 - شماره پیاپی 171
بهمن و اسفند 1390
صفحه 2739-2755

فایل ها

سابقه مقاله

  • تاریخ دریافت: 09 آذر 1390
  • تاریخ بازنگری: 03 خرداد 1403
  • تاریخ پذیرش: 17 فروردین 1401

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