نقش لپتین در باروری

نوع مقاله : مقاله بازآموزی

نویسندگان

1 دانشجوی دکترای بیولوژی تولید مثل، گروه آناتومی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی تهران، تهران، ایران.

2 دانشجوی کارشناسی ارشد، گروه فیزیولوژی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

3 گروه فیزیولوژی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

لپتین یک هورمون پپتیدی مترشحه از بافت چربی است که نقش کلیدی در هموستاز انرژی و وزن بدن ایفا می‌کند؛ این ماده در پژوهش‌های اخیر به عنوان یک میانجی نورواندوکرین در سیستم‌های مختلف بدن، از جمله سیستم تولید مثلی، شناخته شده است که به عنوان یک حلقه‌ی کلیدی بین بافت چربی و سیستم تولید مثلی عمل کرده، اعلام می‌کند که ذخیره‌ی کافی انرژی برای عملکرد تولید مثلی طبیعی وجود دارد. لپتین بر سیستم تولید مثل در سطوح مختلف محور هیپوتالاموسی- هیپوفیزی- گنادی اثر گذاشته، دارای تأثیرات فیزیولوژیک مهمی بر بلوغ، حفظ سیکل قاعدگی طبیعی شیردهی و حتی فیزیولوژی نوزاد است. در شرایطی که تغذیه نامناسب باشد و یا در شرایط القا کننده‌ی آمنوره، سطح لپتین سرم پایین و بر عکس در شرایطی مانند ذخیره‌ی بیش از حد انرژی (نظیر چاقی) و در سندرم پلی‌کیستیک تخمدان سطح لپتین سرم و مایع فولیکولی افزایش می‌یابد و این احتمال را ایجاد می‌کند که کمبود لپتین و یا مقاومت به لپتین تا حدی مسؤول ناهنجاری‌های تولید مثلی محسوب می‌شود. به هر حال، نقش دقیق عملکرد لپتین در داخل تخمدان و در فیزیولوژی و پاتوفیزیولوژی انسان نیاز به بررسی‌های بیشتری دارد.

کلیدواژه‌ها

عنوان مقاله [English]

Leptin and Fertility

نویسندگان [English]

  • Fateme Sadat Amjadi 1
  • Ensieh Salehi 2
  • Shaghayegh Haghjooy Javanmard 3
1 PhD Student of Reproductive Biology, Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran.
2 MSc Student, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
3 Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

Leptin, the adipocyte-derived hormone that plays a key role in energy and body weight homeostasis, has recently known as a mediator in the reproductive system. Leptin acts as a link between fat tissue and reproduction in human and is a signal which transmits the information to the brain; where is adequate fat in stores to cover the energy requirements of reproduction. Leptin acts on reproductive system at multiple levels including hypothalamic-pituitary-gonadal axis. It influences puberty, mensturation, pregnancy, and lactation. The nutritional suboptimal conditions such as eating disorders and obesity can influence serum leptin levels and are associated with some reproductive system disorders such as amenorrhea and polycystic ovarian syndrome. Future studies are expected to clarify the exact role of leptin in human reproductive physiology and pathophysiology.Keywords: Leptin, Fertility, Hypothalamic-pituitary-gonadal axis.

کلیدواژه‌ها [English]

  • Leptin
  • Fertility
  • Hypothalamic-pituitary-gonadal axis

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مجله دانشکده پزشکی اصفهان
دوره 28، شماره 121 - شماره پیاپی 121
بهمن و اسفند 1389
صفحه 1701-1713

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سابقه مقاله

  • تاریخ دریافت: 22 آذر 1389
  • تاریخ بازنگری: 11 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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