مقایسه‌ی عملکرد کبدی و کلیوی در پرسنل اتاق عمل و پرستاران شاغل در بیمارستان‌های شهر یزد

نوع مقاله : Original Article(s)

نویسندگان

1 کارشناسی ارشد، گروه مهندسی بهداشت حرفه‌ای، مرکز تحقیقات بهداشت حرفه‌ای، دانشکده‌ی بهداشت، دانشگاه علوم پزشکی شهید صدوقی یزد، یزد، ایران

2 استادیار، گروه مهندسی بهداشت حرفه‌ای، مرکز تحقیقات بهداشت حرفه‌ای، دانشکده‌ی بهداشت، دانشگاه علوم پزشکی شهید صدوقی یزد، یزد، ایران

3 دکترا، گروه مدیریت سلامت، ایمنی و محیط زیست، مرکز تحقیقات بهداشت حرفه ای، دانشکده بهداشت، دانشگاه علوم پزشکی شهید صدوقی

چکیده

مقاله پژوهشی




مقدمه: مواجهه‌ی پرسنل اتاق عمل با برخی مواد شیمیایی شامل فرمالدئید و بیهوش کننده‌های استنشاقی، می‌تواند باعث آسیب‌های کبدی و کلیوی شود. مطالعه‌ی حاضر با هدف بررسی عملکرد کبدی و کلیوی پرسنل اتاق عمل و تعیین ارتباط آن با غلظت فرمالدئید هوای منطقه‌ی تنفسی پرسنل انجام گردید.
روش‌ها: در این مطالعه‌ی توصیفی- مقطعی که در بیمارستان‌های شهر یزد در سال 1401 انجام شد، 150 نفر از پرسنل اتاق‌های عمل به عنوان گروه مواجهه یافته با فرمالدئید و 150 نفر از پرستاران سایر بخش‌های همان بیمارستانها بدون هر گونه سابقه‌ی مواجهه با فرمالدئید، به عنوان گروه شاهد، انتخاب شدند. پرسش‌نامه‌ای شامل اطلاعات دموگرافیک و سابقه‌ی بیماری‌های زمینه‌ای توسط شرکت‌کنندگان تکمیل شد. 5 سی‌سی نمونه خون ناشتا جهت ارزیابی عملکرد کبدی و کلیوی جمع‌آوری گردید و فرمالدئید در هوای منطقه‌ی تنفسی کارکنان به روش 3500 NIOSH تعیین شد.
یافته‌ها: میانگین غلظت فرمالدئید در هوای منطقه‌ی تنفسی پرسنل ppm 2/87 ± 3/34 بود که بطور معنی‌داری بیشتر از ppm 0/1 یعنی حدود مجاز تعیین شده توسط وزارت بهداشت، درمان و آموزش پزشکی ایران بود. در گروه مواجهه یافته در مقایسه با گروه مواجهه نیافته، سطوح آلکالین فسفاتاز (Alkaline phosphatase) ALP و آسپارتات آمینوترانسفراز (Aspartate aminotransferase) AST به عنوان بیومارکر آسیب کبدی و سطح سرمی کراتینین به عنوان بیومارکر آسیب کلیوی بطور معنی‌داری بیشتر بود.
نتیجه‌گیری: نتایج مطالعه‌ی حاضر، ارتباط آماری معنی‌داری را بین غلظت بالای فرمالدئید و بالا بودن آنزیم‌های کبدی و کراتینین سرم در پرسنل اتاق‌های عمل بیمارستان‌های یزد نشان داد.

تازه های تحقیق

فاطمه کارگر شورکی: PubMed, Google Scholar

روح الله فلاح مدواری: PubMed, Google Scholar

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Comparison of Liver and Kidney Functions in Operating Room Personnel and Nurses in Yazd Hospitals

نویسندگان [English]

  • Marzieh Baharlouei 1
  • Fatemeh Kargar-Shouroki 2
  • Roohollah Fallah Madvari 2
  • Mohammad Ali Ghoveh Nodoushan 3
1 MSc, Department of Occupational Health Engineering, Occupational Health Research Center, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2 Assistant Professor, Department of Occupational Health Engineering, Occupational Health Research Center, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3 Ph.D, Department of Health, Safety and Environment Management, Occupational Health Research Center, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
چکیده [English]

Background: Exposure of operating room personnel to some chemicals, including formaldehyde (FA) and inhalational anesthetics can cause liver and kidney damage. This study was performed to assess liver and kidney functions and to determine the FA concentration in the breathing zone of operating room personnel.
Methods: In this cross-sectional study that was conducted in Yazd hospitals in 2022, 150 operating room personnel exposed to formaldehyde, and 150 nurses from other departments of the same hospitals (control group) without any history of exposure to formaldehyde, were selected. A questionnaire including demographic information and history of systemic diseases was completed by the participants. 5 cc of fasting blood samples were collected to evaluate liver and kidney functions. FA concentration was determined by the NIOSH 3500 method.
Findings: The mean concentration of FA in the breathing zone of operating room personnel was 3.34 ± 2.87 ppm, which was significantly higher than the Occupational Exposure Limit (OEL) of 0.1 ppm proposed by Iran's Ministry of Health and Medical Education. The levels of alkaline phosphatase (ALP) and aspartate aminotransferase (AST) as biomarkers of liver damage, and serum creatinine as a biomarker of kidney damage were significantly higher, in the exposed group than in the non-exposed group.
Conclusion: The findings of the present study showed a statistically significant association between high concentration of formaldehyde and high levels of liver enzymes and serum creatinine in the operating room personnel in Yazd hospitals.

کلیدواژه‌ها [English]

  • Creatinine
  • Formaldehyde
  • Liver function enzymes
  • Operating room nursing
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