Background: United anterior, middle, and posterior clinoid processes convert the distal end of the carotid sulcus into an ostium called the caroticoclinoid foramen (CCF). The internal carotid artery (ICA) traverses through the CCF. The CCF can be the result of ossification of the caroticoclinoid ligament (CCL) or a dural fold extending between the anterior and middle or occasionally posterior clinoid processes of the sphenoid bone. The presence of the bony CCF makes the removal of the anterior clinoid process more difficult and increases the risks and chances of ischemic and neurological disorders. The aim of this study was to survey the prevalence of CCF in skulls available at the Department of Anatomy of Isfahan University of Medical Sciences (Isfahan, Iran). Methods: Overall, 15 dry skulls with removed calvaria were studied. The length and type of CCF were measured using a caliper. The obtained data was statistically analyzed using Mann-Whitney U test. Findings: Incomplete CCF was the most prevalent type. Two skulls with complete CCF were found. In addition, four skulls had healthy CCF. Conclusion: It can be concluded that the ossification of CCL is common. Therefore, neurosurgeons should be provided with a comprehensive database about its incidence and the prevalence of its significant complications. Keywords: Caroticoclinoid foramen, Ossification, Sphenoid, Sella-turcica, Dry skull