دوره 31، شماره 227: هفته اول اردیبهشت ماه 1392:224-236

نقش انسولین در عملکردهای شناختی در سیستم مرکزی اعصاب

سعیده داوری, پرهام رئیسی

چکیده


پیش از این باورها بر این بود که انسولین تنها دارای عملکرد محیطی است و قادر به عبور از سد خونی- مغزی و تأثیر بر سیستم اعصاب مرکزی نیست. اما اکنون مشخص شده است که انسولین و گیرنده‌های آن در سیستم اعصاب مرکزی وجود دارند. این هورمون نه تنها از سد خونی- مغزی عبور می‌کند، بلکه ممکن است توسط نورون‌های مغز نیز سنتز ‌شود و به عنوان یک نوروپپتید نقش بارزی در تکامل و همچنین عملکردهای سیستم عصبی داشته باشد. کمبود این هورمون یا اختلال در گیرنده‌های مرکزی آن موجب آسیب جدی فرایندهای شناختی و از جمله یادگیری و حافظه می‌شود که ممکن است ناشی از اثرات غیر متابولیک آن باشد. هدف این مقاله‌ی مروری، نگاه کلی به نقش انسولین در رابطه با فرایندهای عصبی بود.


واژگان کلیدی


انسولین؛ سیستم مرکزی اعصاب؛ یادگیری؛ حافظه؛ دیابت

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