دوره 31، شماره 228: هفته دوم اردیبهشت ماه 1392:274-293

P-گلیکوپروتئین 170؛ اهمیت بالینی و عملکرد پاتوفیزیولوژیک آن در سرطان

مرجان عابدی, سهیلا رهگذر

چکیده


مقدمه: P- گلیکوپروتئین 170 توسط ژن MDR1 کد می‌شود و به خانواده‌ی انتقال دهنده‌ها‌ی ATP binding cassette (ABC) تعلق دارد. این پروتئین اعمال مهمی را در فیزیولوژی سلولی بر عهده داشته، عملکرد آن در سلول‌های سرطانی منجر به شکست درمان می‌گردد. در این مطالعه، ساختار P- گلیکوپروتئین و ژن آن معرفی شده است. علاوه بر این، نقش پاتوفیزیولوژیک این پروتئین و تأثیر آن بر فارماکوکینتیک مورد بحث قرار گرفته است.

روش‌ها: به منظور معرفی جدیدترین مطالعات در رابطه با P- گلیکوپروتئین، MDR1 و اهمیت بالینی آن‌ها در سلامتی و بیماری، پایگاه‌های داده‌ی EBSCO، Elsevier، PubMed و OVID مورد بررسی قرار گرفت. همچنین، به بحث یافته‌های اخیر نویسندگان در زمینه‌ی MDR1 و لوسمی پرداخته شده است.

یافته‌ها: P- گلیکوپروتئین به طور طبیعی در بسیاری از بافت‌ها شامل کبد، روده و مغز بیان می‌شود. این پروتئین در بسیاری از فرایندهای سلولی از قبیل التهاب، تمایز سلول‌های ایمنی، سمیت‌زدایی و ترشح هورمون‌ها نقش دارد. کاهش کارایی درمان و عود بیماری متعاقب آن به علت مقاومت دارویی مهم‌ترین پیامد عملکرد این پروتئین بوده است و به عنوان یکی از پر چالش‌ترین موانع در درمان سرطان مورد توجه می‌باشد.

نتیجه‌گیری: P- گلیکوپروتئین یک انتقال دهنده‌ی مهم با نقش حفاظتی در حیات سلول طبیعی است. از طرفی، در برخی سلول‌های سرطانی می‌تواند عامل مقاومت دارویی باشد. مطالعات جامع در رابطه با MDR1 و P- گلیکوپروتئین 170 می‌تواند روش‌های جدید تشخیصی و درمانی را فراهم نماید.


واژگان کلیدی


P - گلیکوپروتئین؛ MDR1؛ انتقال دهنده‌؛ مقاومت دارویی، اهمیت بالینی

تمام متن:

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