دوره 31، شماره 234: هفته چهارم خردادماه 1392:568-580

پره‌اکلامپسی از دیدگاه سلولی و ملکولی

طیبه امیریان, سهیلا رهگذر, زهرا شهشهان

چکیده


مقدمه: پره‌اکلامپسی یک اختلال سیستمیک مختص به دوران بارداری است که در 3-5 درصد از بارداری‌ها رخ می‌دهد و عامل اصلی مرگ و میر مادر و نوزاد در سطح جهان، به شمار می‌رود. با وجود دهه‌ها تحقیق و پژوهش، علت این بیماری ناشناخته باقی مانده است و تشخیص آن، قبل از بروز علایم، امکان‌پذیر نمی‌باشد.این مقاله‌ی مروری جنبه‌های مختلف پره‌اکلامپسی را به منظور تشریح پاتوفیزیولوژی آن، بررسی کرد.

روش‌ها: مطالعه‌ی کنونی با استفاده از پایگاه‌های اطلاعاتی Ebsco، OVID، Pubmed،  Elsevierو NCBI، به بررسی 96 مقاله منتشرشده پرداخت تا جنبه‌های مختلف پره‌اکلامپسی را شامل سبب‌شناسی، ژنتیک، پروتئومیکس و متابولومیکس تشریح کند.

یافته‌ها: بر اساس مطالعات منتشرشده، نقص عملکرد اندوتلیالی و استرس اکسیداتیو، مشکلات اصلی در پره‌اکلامپسی هستند. تاکنون ژن‌های مرتبط و بیومارکرهای مختلفی، گزارش شده‌اند که امید می‌رود بتوانند تشخیص پره‌اکلامپسی را بهبود بخشند. علاوه بر این، پروتئومیکس و متابولومیکس، بینش‌های جدیدی را در رابطه با فهم عوامل ایجادکننده‌ی بیماری و همچنین درمان آن فراهم آورده‌اند.

نتیجه‌گیری: پره‌اکلامپسی یک بیماری پیچیده و چند عاملی است که باید از جهات گوناگون مورد ارزیابی قرار گیرد. این مقاله مروری روش‌های جدید برای تشخیص و درمان این اختلال را معرفی می‌نماید.


واژگان کلیدی


پره‌اکلامپسی؛ تشخیص؛ درمان

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مراجع


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