دوره 31، شماره 246: هفته چهارم شهریور ماه 1392:1149-1162

عوامل ژنتیکی ناباروری در مردان

آرزو کرم‌زاده, ها‌دی میرزاپور, مجید خیراللهی

چکیده


ناباروری یکی از شایع‌ترین مشکلات بهداشتی جهان است. این مشکل حدود 15 درصد زوج‌ها را درگیر می‌کند. در حدود نیمی از این موارد یک عامل مردانه دخیل است. سبب‌شناسی ناباروری در مردان به صورت چند عاملی است و بسیاری از عوامل ژنتیکی و محیطی در بروز آن دخیل هستند. عوامل ژنتیکی شامل ناهنجاری‌های کروموزومی و جهش‌های تک ژنی مسؤول حدود 10 تا 15 درصد عوامل در مردان نابارور است. در این مقاله ما به جنبه‌ها‌ی ژنتیکی (ناهنجاری کروموزومی، تک ژنی و پلی‌مورفیسم ژن‌های دخیل)، نقش جهش‌های میتوکندریایی، ارتباط miRNA با ناباروری و گزارش ژن‌های جدید در ناباروری در سال‌های اخیر پرداختیم.

 


واژگان کلیدی


ناباروری؛ اسپرماتوژنز؛ ناهنجاری کروموزومی؛ اپی‌ژنتیک

تمام متن:

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