دوره 31، شماره 265: هفته سوم بهمن ماه 1392:2097-2112

تأثیرات بیولوژیک و ضد سرطانی کورکومین (Curcumin)

الهه کمالی, کامران قائدی, پدیده کریمی, پریسا خردمند, منوچهر توسلی

چکیده


زردچوبه، نام عامیانه‌ی گیاه Curcuma longa، یک ادویه‌ی هندی متعلق به خانواده‌ی زنجبیل است. زردچوبه علاوه ‌بر استفاده به عنوان ادویه و رنگ‌ دهنده به غذا، به طور سنتی برای درمان بیماری‌های مختلف از جمله التهاب مفاصل، زخم معده، زردی، ترمیم زخم، تب، تروما و بیماری‌های پوستی نیز کاربرد داشته است. خواص دارویی و اثرات بیولوژیک زردچوبه در اصل با جزء اصلی موجود در ریزوم آن یعنی Curcumin مرتبط است. در این مقاله مکانیسم‌هایی که به واسطه‌ی آن، کورکومین خواص ضد سرطانی خود را القا می‌کند، مورد بررسی قرار گرفت. کورکومین دارای خواص آنتی ‌اکسیدانی، ضد ‌باکترایی، ضد ‌قارچی، ضد ‌ویروسی، ضد ‌التهابی، ضد ‌رشدی و پروآپوپتوتیک است و پتانسیل درمانی فوق‌العاده‌ای در برابر انواعی از سرطان‌ها دارد. کورکومین فعالیت ضد سرطانی خود را از طریق مهار مسیرهای التهابی، توقف سیکل سلولی، القای آپوپتوز و مهار آنژیوژنز و متاستاز در سلول‌های سرطانی، القا می‌کند.

 


واژگان کلیدی


کورکومین؛ سرطان؛ التهاب؛ دسترسی زیستی

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