دوره 32، شماره 295: هفته چهارم شهریورماه 1393:1197-1215

بروسلا: بیماری‌زایی، واکنش سیستم ایمنی و واکسن

امیر قاسمی, علیرضا رنجبر

چکیده


باکتری‌های جنس بروسلا، پاتوژن‌هایی داخل سلولی هستند که می‌توانند در داخل ماکروفاژهای بدن میزبان خود، تکثیر و به بقای خود ادامه دهند که حاصل آن مشکلات بسیاری برای میزبان به وجود خواهد آورد. نتایج مطالعات اخیر پیشرفت‌هایی در زمینه‌ی چگونگی بقا و تکثیر داخل سلولی این باکتری را نشان می‌دهد. در این مقاله، آخرین یافته‌ها در این زمینه مورد مرور و بررسی قرار می‌گیرد. همچنین واکنش ایمنی بدن میزبان به این پاتوژن و استراتژی‌های جدید به کار رفته به منظور ساخت واکسن علیه این باکتری، بررسی می‌شود.

 


واژگان کلیدی


بروسلا؛ واکسن؛ بیماری‌زایی؛ ماکروفاژ

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