دوره 31، شماره 267: هفته اول اسفند ماه 1392:2193-2208

تلومراز و درمان تومورهای مغزی

مجید خیراللهی, رویا خواجه گودری, رضا قویمی

چکیده


تلومر یک ساختمان ویژه می‌باشد که سبب محافظت انتهای کروموزوم از تحلیل رفتن می‌شود. تلومر در هر بار تقسیم سلولی کوتاه‌تر می‌شود. با این حال، تلومراز آنزیمی است که در سلول‌های سرطانی و رده‌ی زاینده فعال است که تلومر را بازسازی می‌کند. اما در ظاهر ارتباطی بین طول تلومر و فعالیت تلومراز وجود ندارد. فعالیت آنزیم تلومراز با بدخیمی تومور در ارتباط است. به طور کلی، فعالیت تلومراز و درجه‌ی هیستولوژیکی ارتباط نزدیکی با هم دارند و نتیجه‌ی مطالعات مشخص نموده است که فعالیت تلومراز، یک نشانگر مهم بدخیمی در تومورهای مغزی است. به عنوان نتیجه‌گیری نهایی، می‌توان گفت احتمال می‌رود که فعالیت تلومراز می‌تواند به عنوان نشانگر بیولوژیکی در پاسخ به درمان در نظر گرفته شود.


واژگان کلیدی


تلومراز؛ درمان؛ تومور؛ مغز

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