Assessment of Risk Factors for Type I Diabetes Mellitus: A Case-Control Study

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Community Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Associate Professor, Department of Community Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Professor, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

4 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

5 Student of Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Background: Epidemiologic studies show that the prevalence of type I diabetes mellitus is different in several areas in Iran. The aim of this study was comparison of the risk factors of type I diabetes between the children with and without this disease in Isfahan Province, Iran.Methods: In a case-control study during 2013-2014, 175 patients with type I diabetes as case group and 350 healthy children as control group were selected from Imam Hossein hospital and Isfahan Endocrine and Metabolism Research Center. Risk factors of type I diabetes mellitus were compared between the two groups using SPSS software.Findings: Season of birth, number of children, duration of using infant formula, using vitamin D supplement during pregnancy, using vitamin A and D supplement during infancy, family history of types I and II diabetes mellitus, age of attending kindergarten, duration of breast feeding and age of starting supplementary feeding were statistically different between the two groups.Conclusion: According to the result of our study, in addition to genetic factors, several environmental factors have positive roles in the incidence of type I diabetes. Health providers must plan for reducing these risk factors.

Keywords


  1. American Diabetes Association. Standards of Medical Care in Diabetes—2013. Diabetes Care 2013; 36(Suppl 1): S11–S66.
  2. Karvonen M, Viik-Kajander M, Moltchanova E, Libman I, LaPorte R, Tuomilehto J. Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group. Diabetes Care 2000; 23(10): 1516-26.
  3. Rosenbauer J, Herzig P, von Kries R, Neu A, Giani G. Temporal, seasonal, and geographical incidence patterns of type I diabetes mellitus in children under 5 years of age in Germany. Diabetologia 1999; 42(9): 1055-9.
  4. Kappy MS, Allen DB, Geffner ME. Principles and Practice of pediatric endocrinology. 1st ed. Springfield, IL: Charles C Thomas; 2005.
  5. Yang Z, Wang K, Li T, Sun W, Li Y, Chang YF, et al. Childhood diabetes in China. Enormous variation by place and ethnic group. Diabetes Care 1998; 21(4): 525-9.
  6. Hagman E, Reinehr T, Kowalski J, Ekbom A, Marcus C, Holl RW. Impaired fasting glucose prevalence in two nationwide cohorts of obese children and adolescents. Int J Obes (Lond) 2014; 38(1): 40-5.
  7. Larijani B, Zahedi F. Epidemiology of diabetes mellitus in Iran. Iranian Journal of Diabetes and Metabolism 2001; 1(1): 1-8.
  8. Levitsky LL. Misra M. Epidemioloy, presentation and diagnosis of type 1 diabetes mellitus in children and adolescents. UpTodate [Online]. [cited 2017 Jan]; Available from: URL: http://www.uptodate.com/contents/epidemiology-presentation-and-diagnosis-of-type-1-diabetes-mellitus-in-children-and-adolescents?source=search_result &search=Epidemiology%2C+presentation%2C+and+diagnosis+of+type+1+diabetes+mellitus+in+children+and+adolescents&selectedTitle=1%7E150
  9. Silink M. Childhood diabetes: a global perspective. Horm Res 2002; 57(Suppl 1): 1-5.
  10. Bainbridge KE, Hoffman HJ, Cowie CC. Diabetes and hearing impairment in the United States: audiometric evidence from the National Health and Nutrition Examination Survey, 1999 to 2004. Ann Intern Med 2008; 149(1): 1-10.
  11. Bergenstal RM, Tamborlane WV, Ahmann A, Buse JB, Dailey G, Davis SN, et al. Effectiveness of sensor-augmented insulin-pump therapy in type 1 diabetes. N Engl J Med 2010; 363(4): 311-20.
  12. Shahid A, Saeed S, Rana S, Mahmood S. Family history of diabetes and parental consanguinity: important risk for impaired fasting glucose in south east Asians. West Indian Med J 2012; 61(3): 219-23.
  13. Thorn LM, Forsblom C, Waden J, Soderlund J, Rosengard-Barlund M, Saraheimo M, et al. Effect of parental type 2 diabetes on offspring with type 1 diabetes. Diabetes Care 2009; 32(1): 63-8.
  14. El Mouzan MI, Al Salloum AA, Al Herbish AS, Qurachi MM, Al Omar AA. Consanguinity and major genetic disorders in Saudi children: a community-based cross-sectional study. Ann Saudi Med 2008; 28(3): 169-73.
  15. Raab J, Giannopoulou EZ, Schneider S, Warncke K, Krasmann M, Winkler C, et al. Prevalence of vitamin D deficiency in pre-type 1 diabetes and its association with disease progression. Diabetologia 2014; 57(5): 902-8.