دوره 32، شماره 303: هفته چهارم آبان ماه 1393:1594-1604

بررسی ارتباط پلی‌مورفیسم‌های عوامل انعقادی در زنان مبتلا به میوم رحمی

محدثه عرب‌نژاد, احمد ابراهیمی, محبوبه نصیری, مهران کریمی

چکیده


مقدمه: میوم‌ها (لیومیوم یا فیبروئید) تومورهای خوش‌خیم و تک کلونی سلول‌های عضله‌ی صاف دیواره‌ی رحم می‌باشند. ترومبو آمبولی وریدی (VTE یا Venous thromboembolism) از عوارض شایع سرطان است؛ با این حال، سهم عوامل ترومبوتیک در بیماران مبتلا به سرطان نتایج متناقضی دارد. مطالعه‌ی حاضر به منظور بررسی ارتباط بین پلی‌مورفیسم ژن عوامل انعقادی و خطر ابتلا به میوم رحمی طراحی و اجرا شد.

روش‌ها: در مطالعه‌ی حاضر، سه پلی‌مورفیسم ژن عامل انعقادی انتخاب شدند و با استفاده از روش ARMS-PCR (Amplification refractory mutation system- polymerase chain reaction) مورد بررسی قرار گرفتند. در این مطالعه، شیوع پلی‌مورفیسم‌های ژن پروترومبین (A20210G) (PTH یا Prothrombin)، بتا فیبرینوژن (A/G455) (FGB یا Fibrinogen beta) و بازدارنده‌ی فعال كننده‌ی پلاسمینوژن1 (G5/G4) (1-PAI یا 1-Plasminogen activator inhibitor) در 50 زن با تشخیص کلینیکی میوم رحمی و 50 زن سالم مورد بررسی قرار گرفتند. داده‌ها به وسیله‌ی نرم‌افزار SPSS نسخه‌ی 19 و با کمک آزمون 2χ تجزیه و تحلیل شدند.

یافته‌ها: پلی‌مورفیسم‌های (1799963rs) PTH، (1800790rs) FGB و (1799889rs) 1-PAI با افزایش خطر ابتلا به میوم رحمی در جامعه‌ی مورد مطالعه، ارتباط معنی‌داری نداشتند (050/0 < P).

نتیجه‌گیری: هیچ ارتباطی بین پلی‌مورفیسم‌های مورد بررسی و خطر ابتلا به میوم رحمی مشاهده نشد.

 


واژگان کلیدی


عامل انعقادی؛ میوم رحمی؛ پروترومبین A20210G؛ بتا فیبرینوژن A/G455؛ بازدارنده‌ی فعال كننده‌ی پلاسمینوژن1 G5/G4

تمام متن:

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