بررسی ارتباط بین مواجهه با کادمیم و خطر رخداد سرطان پانکراس: مطالعه‌ی مروری نظام‌مند و متاآنالیز

نوع مقاله : مقاله مروری

نویسندگان

1 دانشجوی کارشناسی ارشد مهندسی بهداشت محیط، کمیته‌ی تحقیقات دانشجویی، دانشکده‌ی بهداشت، دانشگاه، علوم پزشکی شهرکرد، شهرکرد، ایران

2 استادیار اپیدمیولوژی، گروه اپیدمیولوژی و آمار زیستی، دانشکده‌ی بهداشت، مرکز تحقیقات مدل‌سازی در سلامت، دانشگاه علوم پزشکی شهرکرد، شهرکرد، ایران

3 دانشیار مهندسی بهداشت محیط، گروه مهندسی بهداشت محیط، دانشکده‌ی بهداشت، دانشگاه علوم پزشکی شهرکرد، شهرکرد، ایران

4 استادیار سم‌شناسی و داروشناسی، گروه مهندسی بهداشت محیط، دانشکده‌ی بهداشت، دانشگاه علوم پزشکی شهرکرد، شهرکرد، ایران

چکیده

مقاله مروری




مقدمه: مواجهه با کادمیم با رخداد سرطان پانکراس مرتبط هستند. در شرایطی که نتایج مطالعات پیشین همسو نمی‌باشند، این مطالعه با استفاده از شیوه‌ی مرور نظام‌مند و متاآنالیز، ارتباط بین مواجهه با کادمیم و خطر رخداد سرطان پانکراس را بررسی کرده تا یک نتیجه‌گیری مناسب در این ‌خصوص ارائه کند.
روش‌ها: با جستجو در پایگاه‌های ISI Web of Science ،Cochrane، Science Direct، Scopus ،PubMed و Google Scholar و استفاده از کلیدواژه‌های (Cadmium, Pancreatic Cancer) و مترادف‌های آن‌ها، 391 مقاله بازیابی و نهایتاً با در نظرگیری معیارهای ورود و خروج، 8 مقاله وارد مطالعه‌ی حاضر شد. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار 15 Stata انجام گردید. سطح معنی‌داری 0/05 در نظر گرفته شد.
یافته‌ها: در این مطالعه‌ی مروری نظام‌مند و متاآنالیز، مشاهده شد که نسبت به گروه بدون مواجهه/ مواجهه با کم‌ترین دوز کادمیم، خطر رخداد سرطان پانکراس در افراد مواجهه یافته/ مواجهه با بالاترین دوز کادمیم برابر با (0/001 ≥ P)، (95% CI: 1/18- 2/21) 1/62 می‌باشد و این ارتباط از لحاظ آماری معنی‌دار است. با توجه ‌به نتایج آزمون Egger (P = 0/100) و Begg (P = 0/076)؛ در این مطالعه تورش انتشار مشاهده نشد.
نتیجه‌گیری: بر اساس نتایج این پژوهش مروری، مواجهه با کادمیم، منجر به افزایش 62 درصد خطر ابتلا به سرطان پانکراس می‌گردد؛ بنابراین می‌توان بیان کرد که مواجهه با کادمیم، یک عامل خطر برای ابتلا به سرطان پانکراس می‌باشد و سیاست‌های بهداشتی باید سمت کاهش مواجهه با کادمیم پیش رود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Investigating the Relationship between Exposure to Cadmium and the Risk of Pancreatic Cancer: A Systematic Review and Meta-Analysis

نویسندگان [English]

  • Parisa Farahmandian 1
  • Abdollah Mohammadian-Hafshejani 2
  • Abdolmajid Fadaei 3
  • Ramezan Sadeghi 4
1 MSc Student in Environmental Health Engineering, Student Research Committee, School of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Assistant Professor of Epidemiology, Department of Epidemiology and Biostatistics, School of Health, Modeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Associate Professor of Environmental Health Engineering, Department of Environmental Health Engineering, School of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran
4 Assistant Professor of Pharmacology and Toxicology, Department of Environmental Health Engineering, School of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran
چکیده [English]

Background: Exposure to cadmium is associated with the occurrence of pancreatic cancer. In a situation where the results of previous studies are not consistent, this study, using a systematic review and meta-analysis method investigated the relationship between exposure to cadmium and the risk of pancreatic cancer in order to provide an appropriate conclusion in this regard.
Methods: By searching the ISI web of science, Cochrane, Science Direct, Scopus, PubMed and Google Scholar databases and using the keywords (Cadmium, Pancreatic Cancer) and their synonyms, 391 articles were retrieved and considering the inclusion and exclusion criteria, finally 8 articles were included in the present study. Data analysis was done using Stata 15 software. The significance level was considered 0.05.
Findings: In this systematic review and meta-analysis study, it was observed that compared to the group without exposure/exposure to the lowest dose of cadmium, the risk of pancreatic cancer in people exposed/exposure to the highest dose of cadmium is equal to 1.62 (95% CI: 1.18-2.21; P ≤ 0.001), this relationship was statistically significant. According to the results of Egger's test (P = 0.100) and Begg's test (P = 0.076); in this study, publication bias was not observed.
Conclusion: According to the results of this Review research, exposure to cadmium leads to a 62% increase in the risk of developing pancreatic cancer. Therefore, it can be said that exposure to cadmium is a risk factor for developing pancreatic cancer and health policies should be aimed at reducing exposure to Cadmium goes forward.

کلیدواژه‌ها [English]

  • Exposure
  • Cadmium
  • Pancreatic cancer
  • Systematic review and meta-analysis

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مجله دانشکده پزشکی اصفهان
دوره 41، شماره 715
هفته 3 خرداد
خرداد و تیر 1402
صفحه 260-269

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