Resuscitation of Preterm Newborn with High Concentration Oxygen Versus Low Concentration Oxygen

Document Type : Original Article (s)

Authors

1 Associate Professor, Department of Pediatrics, Child Health Promotion Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Resident of Neonatology, Department of Pediatrics, Child Health Promotion Research Center, School of Medicine And Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: It is well known that a brief exposure to 100% oxygen for only a few minutes could be toxic to the preterm infant. We compared the effectiveness of neonatal resuscitation with low concentration oxygen (30%) and high concentration oxygen (100%).Methods: Thirty two preterm neonates with gestational age 29-34 weeks who required resuscitation were randomized into two groups. In low concentration oxygen group (LOG), resuscitation begun with 30% O2. Infants were examined every 60 to 90 seconds, and if their heart rate was less than 100, 10% was added to the previous FIO2 until the heart rate increased to 100 and SO2 increased to 85 percent. In high concentration oxygen group (HOG) resuscitation begun with 100% O2 and every 60 to 90 seconds, FIO2 was decreased 10–15% until the heart rate reached to 100 and SO2 reached to 85 percent.Findings: The FIO2 in LOG was increased stepwise to 45% and in HOG was reduced to 42.1% to reach stable oxygen saturation more than 85% at 5th minute in both groups. At first and third minutes after birth and there was no significant differences between groups in heart rate, and after 1, 2, 4 and 5 minutes after birth there was no significant differences in oxygen saturation (SO2) between groups, regardless of the initial FIO2.Conclusion: We can safely initiate resuscitation of preterm infants with a low FIO2 (approximately 30%) oxygen and then oxygen should be adjusted with the neonates needs.

Keywords

References

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Journal of Isfahan Medical School
Volume 29, Issue 145 - Serial Number 145
May and June 2011
Pages 847-854

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History

  • Receive Date: 15 June 2011
  • Revise Date: 23 May 2024
  • Accept Date: 06 April 2022

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