The Success Rate and Postoperative Complications of Trabeculectomy with Mitomycin C among the Patients with Glaucoma

Document Type : Original Article (s)

Authors

1 Professor, Department of Ophthalmology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Student of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

3 Resident, Department of Ophthalmology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: One of the most common ophthalmic diseases is glaucoma that may lead to some of serious complications such as blindness and damage to eye tissue. Glaucoma and be treated by using several methods that one of the most common ones is trabeculectomy. In the other hand, some studies showed that using mitomycin C probably can help the treatment of glaucoma and decrease complications. So, the aim of this study was determining the success rate and postoperative complications of trabeculectomy with and without rubbing mitomycin C in the local operation among the patients with glaucoma.Methods: In a prospective cohort study, 70 patients who were candidates for trabeculectomy were divided in two equal groups. In the first group, mitomycin C was contacted with operation site during surgery and in the second group, only trabeculectomy was done. Intraocular pressure was measured before, one week and one, three and six months after the surgery. In addition, postoperative complications were evaluated until six months after the surgery. The collected data were compared between the two groups.Findings: According to six-month follow-up, the surgery was completely successful in 22 (63.9%) and 28 (80%) patients, relatively successful in 5 (14.3%) and 6 (17.1%) patients and unsuccessful in 8 (22.9%) and 1 (2.9%) patients in control and intervention groups, respectively; The success rate was significantly better in intervention group (P = 0.048).Conclusion: According to results of this study, rubbing mitomycin C in operation site during trabeculectomy increased the success rate and decreased the number of used drugs. So, it is suggested to be used by ophthalmologists.

Keywords

References

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Journal of Isfahan Medical School
Volume 33, Issue 367 - Serial Number 367
November and December 2016
Pages 2400-2406

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History

  • Receive Date: 10 October 2015
  • Revise Date: 20 May 2024
  • Accept Date: 06 April 2022

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