دوره 32، شماره 312: هفته اول بهمن ماه 1393:2085-2093

بررسی ذخیره‌ی ضربان قلب و C-Reactive Protein با حساسیت بالا در افراد با و بدون سندرم متابولیك

جعفر گلشاهی, یوسف خالدی, اسماعیل آقابابایی, معصومه صادقی, محمد هاشمی, حمید صانعی

چکیده


مقدمه: عدم افزایش مناسب ضربان قلب متناسب با ورزش باعث پیش‌آگهی نامناسب بیماران قلبی می‌شود. علاوه بر این، سطوح فاكتورهای التهابی نظیر C-reactive protein با حساسیت بالا (hs-CRP یا High-sensitivity CRP) با آترواسكروز در ارتباط می‌باشد. در این مطالعه، این دو فاكتور در افراد با و بدون سندرم متابولیك بررسی شدند.

روش‌ها: این مطالعه بر روی 123 بیمار با سندرم متابولیك و 203 بیمار بدون سندرم متابولیك كه به طور تصادفی از شركت كنندگان مطالعه‌ی كوهورت اصفهان انتخاب شده بودند، انجام گرفت. اطلاعات دموگرافیك، دور كمر، فشار خون، قد و وزن شركت كنندگان ثبت شد. سپس، سطح سرمی تری‌گلیسرید (Triglyceride یا TG)، قند ناشتای خون ( Fasting blood sugarیا FBS)، كلسترول تام (Total cholesterol یا TC)، لیپوپروتئین با چگالی بالا (High density lipoprotein یا HDL-c)، لیپوپروتئین با چگالی پایین (Low-density lipoprotein یا LDL-c) و hs-CRP اندازه‌گیری شد. تست ورزش بر اساس پروتكل استاندارد Bruce انجام گردید و ذخیره‌ی ضربات قلب (HRR یا Heart rate reserve) ثبت شد. اطلاعات با تنظیم بر اساس سن هر شركت كننده با استفاده از آزمون آماری Student’s t و رگرسیون خطی بررسی شد.

یافته‌ها: متوسط سن در افراد با سندرم متابولیك 60/7 ± 29/54 و در افراد بدون سندرم متابولیك 61/8 ± 16/54 سال بود که تفاوت آماری معنی‌داری نداشت‌. در افراد با و بدون سندرم متابولیك به ترتیب میزان LDL-c برابر 55/29 ± 12/125 و 54/24 ± 17/116 میلی‌گرم بر دسی‌لیتر، میزان TG 49/184 ± 99/259 و 65/61 ± 38/140 میلی‌گرم بر دسی‌لیتر، میزان FBS برابر 46/48 ± 13/107 و 90/9 ± 81/81 میلی‌گرم بر دسی‌لیتر، میزان فشار خون سیستولیك برابر 15/15 ± 73/130 و 69/13 ± 06/116 میلی‌متر جیوه و میزان فشار خون دیاستولیك برابر
70/8 ± 84/28 و 69/6 ± 52/76 میلی‌متر جیوه بود و همه‌ی موارد از نظر آماری اختلاف معنی‌دار داشت. دو گروه از نظر ذخیره‌ی ضربان قلب تفاوت معنی‌داری نداشتند (027/0 = P) ولی میزان hs-CRP در گروه با سندرم متابولیك به وضوح بالاتر بود (02/0 = P).

نتیجه‌گیری: ما در این مطالعه نتوانستیم ارتباطی بین ذخیره‌ی ضربات قلب و سندرم متابولیك نشان دهیم ولی ارتباط بین hs-CRP و سندرم متابولیك نشان‌دهنده‌ی افزایش میزان hs-CRP به عنوان یك فاكتور التهابی در افراد با سندرم متابولیك است.

 


واژگان کلیدی


سندرم متابولیك؛ تست ورزش؛ ذخیره‌ی ضربان قلب؛ hs-CRP

تمام متن:

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