دوره 33، شماره 327: هفته سوم اردیبهشت ماه 1394:355-367

اساس ژنتیک سندرم متابولیک

هاجر میران‌زاده مهابادی , سیده غزاله فاطمی , پروانه نیک‌پور , مجتبی عمادی بایگی , رویا کلیشادی

چکیده


سندرم متابولیک یکی از اختلالات رایج در کودکان است که با مجموعه‌ای از فاکتورهای خطر از قبیل چاقی، افزایش قند خون، تری‌گلیسرید و فشار خون و کاهش لیپوپروتئین با چگالی بالا (High-density lipoprotein یا HDL) همراه است. این اختلال چند عاملی به علت افزایش خطر ابتلا به دیابت نوع 2 و بیماری‌های قلبی- عروقی در بزرگ‌سالی، یکی از علل اصلی مرگ و میر در سراسر جهان است. مطالعات اخیر نشان داده است که این سندرم، شیوع بالایی در کودکان و نوجوانان چاق دارد. اتیولوژی سندرم متابولیک پیچیده است و نتیجه‌ای از برهم‌کنش عوامل ژنتیک و محیطی است که در پیشرفت چاقی، مقاومت به انسولین و چندین فرآیند التهابی تأثیر می‌گذارد. مطالعه روی جوانان ایرانی، شیوع نزدیک به 23 درصد سندرم متابولیک را نشان می‌دهد. در این مقاله‌ی مروری، به تعریف سندرم متابولیک، شیوع، علل ابتلا و مهم‌ترین ژن‌های درگیر در این اختلال اشاره می‌شود.


واژگان کلیدی


سندرم متابولیک؛ مقاومت به انسولین؛ چاقی؛ ژنتیک

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