بررسی تأثیر فیتواستروژن‌ها بر علایم یائسگی: یک مرور نظام‌مند

نوع مقاله : مقاله مروری

نویسندگان

1 دانشیار، مرکز تحقیقات مامایی و بهداشت باروری و گروه مامایی و بهداشت باروری، دانشکده‌ی پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران

2 دانشجوی دکتری تخصصی سلامت باروری، کمیته‌ی پژوهشی دانشجویان، دانشکده‌ی پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران

چکیده

مقدمه: یائسگی به عنوان یکی از مسایل بهداشت باروری زنان دارای اهمیت ویژه‌ای است. کمبود استروژن در این دوران، منجر به عوارض متعددی می‌شود. علاوه بر گرگرفتگی که مهم‌ترین علامت یائسگی است، زنان ممکن است خشکی واژن، اختلالات خواب، افسردگی، کاهش تراکم استخوان و بیماری‌های قلبی- عروقی را نیز تجربه کنند. به منظور کاهش مشکلات تهدید کننده‌ی زندگی، زنان یائسه از درمان‌های مختلفی نظیر روش جایگزین هورمونی استفاده می‌کنند. در بین درمان‌های جایگزین، فیتواستروژن‌ها جایگاه خاصی دارند. این مطالعه، با هدف بررسی تأثیر فیتواستروژن‌ها بر علایم یائسگی انجام شد.روش‌ها: مطالعه‌ی حاضر، یک مرور سیستماتیک بر روی بررسی‌های انجام شده می‌باشد. جستجو در پایگاه‌های اطلاعاتی Science direct، Scopus، Pubmed، EMBASE، Google scholar، Scientific Information Database (SID) و IranMedex بین سال‌های 2017-2013 با استفاده از کلید واژه‌های یائسگی، کلیماتریک، فیتواستروژن‌ها، ایزوفلاون‌ها و استروژن‌های غیر استروئیدی همراه با علایم یائسگی انجام شد.یافته‌ها: در نهایت، 25 مقاله شامل 7 متاآنالیز، 14 کارآزمایی بالینی، 2 مطالعه‌ی هم‌گروهی و 2 مطالعه‌ی مقطعی، درباره‌ی اثر فیتواستروژن‌ها بر علایم یائسگی به دست آمد. این مقالات، اثر فیتواستروژن‌ها را بر افسردگی، واژینیت آتروفیک، گرگرفتگی، شاخص‌های بیماری قلبی- عروقی و فشار خون، عملکرد شناختی، وضعیت استخوان و خطر سرطان زنان مورد بررسی قرار داده بودند.نتیجه‌گیری: فیتواستروژن‌ها به دلیل داشتن خواص استروژنی، برای بهبود علایم یائسگی می‌توانند به عنوان یک درمان پیشنهادی مد نظر قرار گیرند. به این امید که کیفیت زندگی زنان در این دوران حساس از زندگی بهبود یابد.

کلیدواژه‌ها

عنوان مقاله [English]

The Effect of Phytoestrogens on Menopause Symptoms: A Systematic Review

نویسندگان [English]

  • Zohreh Keshavarz 1
  • Samira Golezar 2
  • Mahboubeh Hajifoghaha 2
  • Shiva Alizadeh 2
1 Associate Professor, Midwifery and Reproductive Health Research Center AND Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 PhD Candidate in Reproductive Health, Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده [English]

Background: Menopause is a major concern in women’s productivity. Low estrogen in this period brings about many complications. Besides hot flashes, which are the most common menopausal symptom, women might experience vaginal dryness, sleeping disorders, depression, low bone density, as well as cardiovascular diseases. To decrease these life-threatening complications, postmenopausal women receive varying treatments including hormone replacement therapy (HRT). Among the replacement therapies, phytoestrogens are special. The present study was conducted to investigate the effect of phytoestrogens on menopause symptoms.Methods: This was a systematic review of the previous studies. The search was conducted through Science Direct, Scopus, PubMed, EMBASE, Google Scholar, Scientific Information Database (SID) and IranMedex databases during 2013-2017, using the keywords menopause, climacteric, phytoestrogens, isoflavones, non-steroidal estrogen, and menopausal symptoms.Findings: Ultimately, 25 articles, including 7 meta-analyses, 14 clinical trials, 2 cohort studies, and 2 cross-sectional ones were found focusing on the effect of phytoestrogens on menopause symptoms. These studies measured the effect of phytoestrogens on depression, vaginite atrofica, hot flashes, cardiovascular diseases indices and blood pressure, bone status, and the risk of cancer in women.Conclusion: The results revealed that having estrogenic effects, the phytoestrogens could be considered as a proposed treatment to relieve menopause symptoms in the hope of improving women’s quality of life during this time span.

کلیدواژه‌ها [English]

  • Phytoestrogens
  • Menopause
  • Systematic Review

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مجله دانشکده پزشکی اصفهان
دوره 36، شماره 477 - شماره پیاپی 477
خرداد و تیر 1397
صفحه 446-459

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  • تاریخ دریافت: 27 دی 1396
  • تاریخ بازنگری: 11 آبان 1403
  • تاریخ پذیرش: 17 فروردین 1401

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