Comparative Analysis of APC Tumor Suppressor Protein Expression in Cancerous and Normal Colorectal Specimens by Immunohistochemistry

Document Type : Original Article (s)

Authors

1 Associate Professor, Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: APC is a tumor-suppressor protein. To evaluate the correlation between APC expression and pathogenesis of colorectal cancer, we investigated the expression of this protein in cancerous and normal colorectal tissues.Methods: APC expression was evaluated in 50 pairs of primary colorectal cancers and corresponding normal colorectal tissues using immunohistochemical staining on paraffin-embedded sections.Findings: APC was expressed in all tissues. It was down-regulated in the colorectal cancer specimens compared with the matched normal tissues (P < 0.001). Conclusion: APC expression may be a favorable biologic marker and a useful prognostic indicator in patients with colorectal cancer.

Keywords

References

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Journal of Isfahan Medical School
Volume 29, Issue 161 - Serial Number 161
September and October 2011
Pages 1815-1821

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History

  • Receive Date: 15 August 2011
  • Revise Date: 26 May 2024
  • Accept Date: 06 April 2022

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