دوره 32، شماره 320: ویژه نامه (طب مکمل) 1393:2473-2483

بررسی تأثیر مکمل‌یاری پودر گیاه شوید بر مقاومت انسولینی و نشانگرهای التهابی در بیماران مبتلا به دیابت نوع 2

لاله پیاهو, یاسر خواجه بیشک, مجید مبصری, علیرضا استاد رحیمی, محمد اصغری جعفرآبادی

چکیده


مقدمه: بیماری دیابت اختلالی است که با بروز بسیاری از بیماری‌های مزمن ارتباط دارد. افزایش سطوح سیتوکین‌های التهابی، از جمله اینترلوکین 6 (6-IL یا 6-Interleukin)، عامل نکروز توموری-آلفا (TNF-α یا Tumor necrosis factor alpha) و پروتئین واکنشی C (hs-CRP یا High-sensitivity C-reactive protein)، بر حساسیت انسولینی تأثیر می‌گذارد. در سال‌های اخیر، استفاده از گیاهان سنتی به دلیل عوارض جانبی پایین، رواج بیشتری یافته است. مطالعه‌ی حاضر با هدف تعیین تأثیر مکمل‌یاری پودر گیاه شوید بر مقاومت انسولینی و نشانگرهای التهابی در بیماران مبتلا به دیابت نوع 2 انجام شد.

روش‌ها: این مطالعه‌‌ی کارآزمایی بالینی دو سو کور، بر روی 60 بیمار مبتلا به دیابت نوع 2 در شهر تبریز انجام شد. افراد حایز شرایط، به صورت تصادفی به دو گروه مورد و شاهد تقسیم شدند. افراد گروه مورد، روزانه 3/3 گرم پودر گیاه شوید و افراد گروه شاهد، مقادیر مشابه پودر نشاسته را به مدت 8 هفته دریافت کردند. در ابتدا و انتهای مطالعه، غلظت انسولین ناشتا، 6-IL و TNF-α با استفاده از روش ELISA (Enzyme-linked immunosorbent assay) و hs-CRP با استفاده از اسپکترومتری اندازه‌گیری شد. شاخص مقاومت انسولینی با استفاده از فرمول گلوگز ناشتا (mg/dl) × انسولین ناشتا (μU/ml) /405 به دست آمد.

یافته‌ها: کاهش معنی‌داری در غلظت انسولین ناشتا و سیتوکین‌های التهابی 6-IL، TNF-α و hs-CRP در گروه مورد مشاهده شد (050/0 > P). پس از تعدیل بر روی مقادیر پایه و متغیرهای مخدوشگر، این معنی‌داری تأیید شد. شاخص مقاومت انسولینی در هر دو گروه تغییرات آماری معنی‌داری نشان نداد.

نتیجه‌گیری: پودر گیاه شوید، تأثیر مفیدی در کاهش نشانگرهای التهابی و غلظت انسولین ناشتا داشت. با این وجود، انجام مطالعات بیشتر برای تأیید نتایج به دست آمده پیشنهاد می‌گردد.


واژگان کلیدی


پودر گیاه شوید؛ مقاومت انسولینی؛ نشانگرهای التهابی؛ دیابت نوع

تمام متن:

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