Comparison of the Effectiveness of Vitamin D, Integrated Cognitive Rehabilitation Therapy, Transcranial Alternating Current Stimulation on Depression in Patients with Mild Cognitive Impairment

Document Type : Original Article(s)

Authors

1 PhD Student, Department of Psychology, School of Literature and Humanities’Sciences, Lorestan University, Lorestan, Iran

2 Associate Professor, Department of Psychology, School of Literature and Humanities’Sciences, Lorestan University, Lorestan, Iran

3 Professor, Department of Psychology, School of Literature and Humanities’Sciences, Lorestan University, Lorestan, Iran

4 Associate Professor, Department of Internal Medicine, Ayatollah Taleghani Hospital, Research Development Unit, Shahid Beheshti University of Medical Sciences, Tehran, Iran

10.48305/jims.v42.i755.0058

Abstract

Background: Depression is a predictor of cognitive impairment in aged people. This study aimed to compare the effect of Vitamin D, integrated cognitive rehabilitation therapy (CRT), transcranial alternating current stimulation (tACS), and a combination of CRT and tACS on depression in patients with mild cognitive impairment (MCI).
Methods: The present study is a semi-experimental clinical trial study in which 32 people with mild cognitive impairment were randomly assigned to four treatment groups after completing the Beck Depression Test and the Mocha Test. CRT, tACS, and CRT + tACS interventions were held twice a week for 12 sessions each. Each session of CRT and tACS lasted 20 minutes, and each session of cognitive rehabilitation treatment plus TACS was performed for 40 minutes, and the group receiving vitamin D; received 20 micrograms equivalent to 800 IU of vitamin D daily for six weeks. Before conducting the research, the Beck depression test (BDI) and MoCA test were taken, and at the end of the research, BDI was taken to check the effectiveness of treatments on reducing depression. To analyze the results, the repeated measurement statistical test with a significance level of less than 0.05 was used.
Findings: The results showed that the depression scores decreased significantly in the cognitive rehabilitation intervention group from 11 to 9. However, no significant difference was observed in the transcranial alternating current stimulation (tACS) and combination of CRT and tACS and vitamin D groups.
Conclusion: According to the present study, CRT decreased depression scores in MCI, and it is more effective in reducing depression compared to tACS, CRT+tACS, and vitamin D.

Highlights

Fariba Ebahimbabaie: Google Scholar

Kourosh Amraei: Google Scholar, PubMed

Firouzeh Ghazanfari: Google Scholar, PubMed

Parisa Taheri Tanjani: Google Scholar, PubMed

 

Keywords

Main Subjects

References

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Journal of Isfahan Medical School
Volume 42, Issue 755
3rd Week, April
March and April 2024
Pages 58-68

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History

  • Receive Date: 19 August 2023
  • Revise Date: 03 February 2024
  • Accept Date: 03 February 2024

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