دوره 34، شماره 372: هفته چهارم فروردین ماه 1395:148-156

چاقی و التهاب: نقش آدیپوکین‌ها

مجید خزاعی , رضا روزبهانی

چکیده


 با توجه به شیوع چاقی و افزایش عوارض ناشی از آن، شناخت عملکرد بافت چربی و عوامل مترشحه‌ی آن و اثرات آن‌ها بر بافت‌های مختلف بدن، بسیار ضروری به نظر می‌رسد. مطالعات اخیر نشان داده‌اند در چاقی یک التهاب مزمن خفیف (Chronic Low-grade inflammation) وجود دارد که می‌تواند در پاتوژنز عوارض ناشی از چاقی نقش داشته باشد. بافت چربی مقدار زیادی مواد ترشح می‌کند که به عنوان آدیپوکین شناخته می‌شوند. این مواد، می‌توانند اثرات مختلف پیش‌ التهابی یا ضد التهابی داشته باشند. پیشنهاد شده است عدم تعادل در ترشح آدیپوکین‌ها در افراد چاق، می‌تواند در ایجاد عوارض چاقی نقش داشته باشد. در این مقاله‌ی مروری، ارتباط چاقی و التهاب و نقش آدیپوکین‌ها در این فرایند پرداخته می‌شود.


واژگان کلیدی


چاقی؛ التهاب؛ آدیپوکین

تمام متن:

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