Allelic Frequency of Two Polymorphisms (rs1815739) and (rs2228570) in Alpha-actinin3 and Vitamin D Absorption Receptor Genes in Athletes Population

Document Type : Original Article (s)

Authors

1 MSc in Genetics, Department of Biology, School of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran

2 Professor, Department of Biology, School of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran

3 Assistance Professor, Department of Sport Physiology, School of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran

4 Assistant Professor, Department of Biology, School of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran

5 MSc, Department of Sport Physiology, School of Sport Sciences, Shahid chamran university of Ahvaz, Ahvaz, Iran

Abstract

Background: Today, by determining the genotype, genetic science can check in which sport a person can perform more successfully.In this study, two important polymorphisms; one is ACTN3, which plays an essential role in the formation of the diversity of muscle fibers, and the other is VDR, which plays a vital role in the growth of muscle fibers and bones, were investigated.
Methods: In this study, 200 male and female professional athletes, with normal BMI and at least five years of previous professional sports, in the age range of 20-35 years with a peak power score of 1000-1100 W in the male population; and Peak power: 700-750 W in the female population by examining the Wingate test, and the minimum muscle percentage of SMM: 30% were selected according to the body composition machine analyzes and compared with the control group of 200 people. After sampling and DNA extraction, polymorphisms were analyzed using the RFLP-PCR technique analysis software.
Findings: The results of the present study showed that there is a significant difference between the muscle mass indices and the Wingate test score between the male and female populations in the ratio of control samples, also significant differences were observed for the rs1815739 polymorphism in the heterozygous state and the rs2228570 polymorphism in the homozygous form.
Conclusion: It seems that in the polymorphism of rs1815739, athletes need both types of fast and slow twitch muscle fibers for their success, and moreover the existence of more homozygous GG in the polymorphism of rs2228570 has helped athletes absorb vitamin D better.

Keywords

Main Subjects


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Volume 41, Issue 733
1st Week, November
November and December 2023
Pages 743-750
  • Receive Date: 17 July 2023
  • Revise Date: 20 September 2023
  • Accept Date: 21 September 2023