دوره 34، شماره 377: هفته اول خرداد ماه 1395:307-314

اثرات تضعیفی عصاره‌ی آبی دارچین بر یادگیری و حافظه‌ی فضایی رت صحرایی نر مبتلا به دیابت شده با استرپتوزوتوسین

سمیه شریف‌زاده , مهدی محمدزاده

چکیده


مقدمه: دارچین (Cinnamonum verum) دارای اثرات درمانی همچون ضد دیابت، کاهش دهنده‌ی وزن، چربی و قند خون می‌باشد. هدف از انجام این مطالعه، بررسی اثرات عصاره‌ی آبی دارچین بر یادگیری و حافظه‌ی ‌فضایی در رت‌های مبتلا به دیابت بود.

روش‌ها: در این بررسی، 28 سر رت نر بالغ از نژاد ویستار (Wistar) با محدوده‌ی وزنی 30 ± 200 گرم استفاده شد. رت‌ها به چهار گروه هفت‌تایی شاهد یا سالم، سالم دریافت کننده‌ی عصاره، مبتلا به دیابت و مبتلا به دیابت دریافت کننده‌ی عصاره تقسیم شدند. القای دیابت با تزریق داخل صفاقی 50 میلی‌گرم بر کیلوگرم استرپتوزوتوسین انجام شد. آزمایش‌ها برای سه هفته طراحی شد. در این مدت، تیمار با استفاده از عصاره با دز 200 میلی‌گرم بر کیلوگرم انجام شد. در پایان دوره، وزن رت‌های تحت تیمار با گروه شاهد مقایسه گردید. سنجش یادگیری و حافظه‌ی فضایی به کمک ماز شعاعی هشت بازویی انجام شد. داده‌ها با نرم‌افزار SPSS و با استفاده از آزمون Repeated measures ANOVA تحلیل شد.

یافته‌ها: افزایش معنی‌دار (05/0 > P) در زمان سپری شدن برای یافتن غذا در رت‌های مبتلا به دیابت، دریافت کننده‌ی عصاره و مبتلا به دیابت دریافت کننده‌ی عصاره در مقایسه با گروه شاهد، نشان دهنده‌ی اثرات تضعیفی دارچین روی یادگیری و حافظه‌ی فضایی رت‌ها بود.

نتیجه‌گیری: عصاره‌ی آبی دارچین، منجر به تضعیف یادگیری و حافظه‌ی فضایی رت‌های مبتلا به دیابت می‌شود. احتمال می‌رود این اثر تضعیفی در رت‌های دیابتی دریافت کننده‌ی دارچین، ناشی از افزایش قند خون و اثرات مخرب آن بر عملکرد سیستم عصبی باشد.


واژگان کلیدی


دارچین؛ یادگیری؛ حافظه‌ی فضایی؛ رت صحرایی؛ دیابت؛ ماز شعاعی

تمام متن:

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