بررسی مقایسه‌ی دو دز متفاوت سولفات منیزیم برای پیشگیری از درد ناشی از تزریق اتومیدیت

نوع مقاله : Original Article(s)

نویسندگان

1 استاد، گروه بیهوشی و مراقبت‌های ویژه، دانشکده‌ی‌ پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

2 دانشجوی پزشکی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

10.48305/jims.v43.i837.1401

چکیده

مقاله پژوهشی




مقدمه: اتومیدیت، یک داروی نسبتاً ایمن است که در بیهوشی‌های کوتاه‌مدت استفاده می‌شود. با وجود فواید زیاد، بیماران از درد هنگام تزریق شاکی هستند. مطالعات قبلی دوز 620 میلی‌گرم سولفات منیزیم به منظور کاهش درد بیماران توصیه کرده‌اند. در این مطالعه ما سعی کردیم دوز‌های متفاوت سولفات منیزیم برای پیشگیری از درد ناشی از تزریق اتومیدیت و عوارض ناشی از آن بررسی کنیم.
روش‌ها: در این مطالعه کارآزمایی بالینی سه سوکور، 90 نفر از بیماران65-18 سال کاندید بیهوشی عمومی پس از تطبیق معیارهای ورود و خروج، به صورت تصادفی در سه گروه (منیزیم سوالفات 50 درصد، 750 میلی‌گرم، منیزیم سوالفات 50 درصد، 1 گرم و نرمال‌سالین به عنوان کنترل) تقسیم شدند. و سولفات منیزیم قبل از تزریق داروی اتومیدیت تجویز شدند. بیماران قبل از عمل از جهت خصوصیات زمینه‌ای و علائم حیاتی پایش شدند.
یافته‌ها: میانگین سن بیماران 17/22 ± 41/73 سال بود و 75/60 درصد بیماران مرد بودند و فشارخون دیاستولی و ضربان قلب قبل تزریق اتومیدیت در گروه سولفات 50 درصد با دوز یک گرم بیشتر بود (0/05 >P )مدت زمان عمل، بیهوشی و اکستوبیشن در گروه سولفات 50 درصد، 750 میلی‌گرم بیشتر از دوز 1 گرم بود (0/05 > P). شدت درد اولیه و همچنین بعد از 10 دقیقه و تغییرات درد بعد از 10 دقیقه نسبت به درد اولیه در در سه گروه تفاوت نداشت (0/05 <P ). بیماران با دوز دریافتی بالاتر، دچار افزایش فشارخون دیاستولی اما دچار افت فشارخون متوسط در 10 دقیقه ابتدایی شده بودند (0/05 > P).
نتیجه‌گیری: با وجود اینکه دو دز متفاوت منیزیم سولفات اثرات ضد درد قابل توجهی نسبت به یکدیگر نداشتند ولی استفاده از دز یک گرم در مقایسه با 750 میلی‌گرم در کنترل دردهای خفیف تا متوسط موفق‌تر بوده است.

تازه های تحقیق

عظیم هنرمند: Google Scholar, PubMed

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Comparison of Two Different Doses of Magnesium Sulfate on the Prevention of Pain During Etomidate Injection

نویسندگان [English]

  • Azim Honarmand 1
  • Mohammadreza Safavi 1
  • Fatemeh Moazeni 2
1 Professor, Department of Anesthesiology and Critical Care, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Medical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

Background: Etomidate is a relatively safe drug that is used in short-term anesthesia. Despite the many benefits, patients complain of pain during injection. Previous studies have recommended a dose of 620 mg of magnesium sulfate to reduce pain in patients. In this study, we tried to investigate different doses of magnesium sulfate for the prevention of pain caused by etomidate injection and its complications.
Methods: In this triple-blind clinical trial, 90 patients aged 18 to 65 years, who were candidates for surgery under general anesthesia, after meeting the inclusion and exclusion criteria, were randomly divided into three groups (magnesium sulfate 50% 750 mg, magnesium sulfate 50% 1 gram, and normal saline as control). Magnesium sulfate was administered prior to etomidate injection. Patients were monitored for background characteristics and vital signs before surgery.
Findings: The mean age of the patients was 41.73 ± 17.22 years, and 60.75% of the patients were male. The diastolic blood pressure and heart rate before etomidate injection were higher in the 50% magnesium sulfate group with a one-gram dose (P < 0.05). The duration of surgery, anesthesia and extubation in the group receiving 750 mg of 50% magnesium sulfate was longer than that in the 1 gram dose group (P < 0.05). The intensity of initial pain, as well as pain after 10 minutes and the change in pain after 10 minutes compared to the initial pain, did not differ among the three groups (P > 0.05). Patients with a higher dose had an increase in diastolic blood pressure but a decrease in mean blood pressure in the first 10 minutes (P < 0.05).
Conclusion: Although the two different doses of magnesium sulfate did not show significant analgesic effects compared to each other, the use of a 1-gram dose was more successful than 750 mg in controlling mild to moderate pain.

کلیدواژه‌ها [English]

  • Etomidate
  • Magnesium sulfate
  • Pain
  • Hemodynamics

مراجع

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مجله دانشکده پزشکی اصفهان
دوره 43، شماره 837
هفته 1، دی
آذر و دی 1404
صفحه 1401-1410

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سابقه مقاله

  • تاریخ دریافت: 23 مهر 1403
  • تاریخ پذیرش: 01 بهمن 1404

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