Prophylactic Antiemetic Effects of Midazolam, Ondansetron and their Combination after Middle Ear Surgery

Document Type : Original Article (s)

Authors

1 Professor, Department of Anesthesiology, School of Medicine AND Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Student of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: The purpose of the present study was to evaluate the efficacy of midazolam-ondansetron combination in prevention of postoperative nausea and vomiting (PONV) after middle ear surgery and its comparison with using midazolam or ondansetron alone.Methods: 140 patients were divided to four groups to received midazolam 0.75 mg/kg, ondansetron 4 mg, midazolam 0.75 mg/kg and ondansetron 4 mg or normal saline 0.9% (as control) intravenously just before the anesthesia. Assessment of nausea, vomiting, rescue antiemetic and side effects of study drugs such as headache and dizziness were carried out postoperatively for 24 hours.Findings: The incidence of postoperative nausea and vomiting was significantly lower in midazolam-ondansetron group compared to midazolam and ondansetron groups (P < 0.001) and there was no significant difference between the two last groups during the first 24 hours postoperatively. Need to the additional antiemetic was significantly more in the control group (71.4%) compared to other three groups; and in midazolam-ondansetron group (11.4%), it was lower than the midazolam (31.4%) and ondansetron (34.3%) groups (P < 0.001).Conclusion: Our study showed that prophylactic administration of midazolam 0.75 mg/kgcombined with ondansetron 4 mg was more effective than using midazolam or ondansetron alone in prevention of PONV after middle ear surgery.

Keywords

References

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Journal of Isfahan Medical School
Volume 33, Issue 363 - Serial Number 363
November and December 2016
Pages 2187-2192

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History

  • Receive Date: 19 September 2015
  • Revise Date: 27 May 2024
  • Accept Date: 06 April 2022

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