مروری بر کاربردهای پزشکی سیانوباکتری‌ها

نوع مقاله : مقاله مروری

نویسندگان

1 استادیار، گروه بیوتکنولوژی، دانشکده‌ی علوم و فناوری‌های همگرا، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران

2 دانشجوی کارشناسی ارشد، گروه بیوتکنولوژی، دانشکده‌ی علوم و فناوری‌های همگرا، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران

10.48305/jims.v42.i755.0069

چکیده

مقاله مروری




مقدمه: متابولیت‌های ثانویه حاصل از سیانوباکتری‌ها، کاربردهای بیوتکنولوژی فراوانی در زمینه‌ی پزشکی دارند. با این حال بر خلاف سایر منابع میکروبی تولید‌کننده‌ی محصولات طبیعی، سیانوباکتری‌ها در طول تاریخ کمتر مورد توجه قرار گرفته‌اند. به همین دلیل هدف از این مقاله‌ی مروری این بود که با بررسی دستاوردهای اخیر در زمینه‌ی پزشکی و درمانی سیانوباکتری‌ها، پتانسیل دارویی این موجودات ارزشمند را بیشتر شناخت.
روش‌ها: در مقاله‌ی حاضر، مقالات مرتبط منتشر شده در سال‌های 2020-2023 در بانک‌های اطلاعاتی Springer، Science Direct،  Scopusو John Wiley جهت به دست آوردن آخرین یافته‌ها در زمینه‌ی کاربردهای پزشکی سیانوباکتری‌ها مورد بررسی قرار گرفتند. در این مقاله مروری با جستجو در سایت MeSH، کلمات کلیدی مناسب انتخاب گردید و بر اساس آن‌ها، 66 مقاله جدید مروری و تحقیقاتی، جمع‌آوری گردید.
یافته‌ها: بسیاری از مولکول‌های فعال زیستی مشتق شده از سیانوباکتری‌ها، طیف وسیعی از فعالیت‌های ضد میکروبی، ضد باکتریایی، ضد ویروسی، ضد التهابی، ضد تومور، ضد مالاریا، سرکوب‌کننده‌ی سیستم ایمنی و ضد (Human immunodeficiency virus) HIV و همچنین مهار پروتئاز را نشان می‌دهند. در واقع سیانوباکتری‌ها به عنوان یک منبع میکروبی برای تولید داروهای جدید، بسیار با ارزش هستند و فقط به مواد معدنی اولیه برای رشد نیاز دارند.
نتیجه‌گیری: امروزه می‌توان با بهره‌برداری از تکنیک‌های مدرن و استخراج‌های مبتنی بر امواج مایکروویو، امکان جداسازی سریع مواد شیمیایی زیست‌فعال از سیانوباکتری‌ها را فراهم آورد. این روش‌ها، می‌توانند نقش مهمی در توسعه‌ی درمان‌های جدید و همچنین بهره‌برداری بیشتر از سیانوباکتری‌ها در پیشرفت‌های فناوری سبز در آینده فراهم آورد.

تازه های تحقیق

بهاره نوروزی: Google Scholar, PubMed

حسن بیرانوند: Google Scholar

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

A Review of Medical Applications of Cyanobacteria

نویسندگان [English]

  • Bahareh Nowruzi 1
  • Hassan Beiranvand 2
1 Assisstant Professor, Department of Biotechnology, School of Converging Sciences and Technologies, Islamic Azad University, Science and Research Branch, Tehran, Iran
2 MSc Student, Department of Biotechnology, School of Converging Sciences and Technologies, Islamic Azad University, Science and Research Branch, Tehran, Iran
چکیده [English]

Background: Secondary metabolites derived from cyanobacteria exhibit diverse applications in biotechnology, particularly in the field of medicine. Throughout history, cyanobacteria have received less attention compared to other microbial sources of natural products despite their potential. Therefore, this review aims to explore the recent advancements in the medical and therapeutic applications of cyanobacteria, aiming to further understand the valuable medicinal potential of these organisms.
Methods: In this paper, relevant articles published between 2020 and 2023 were scrutinized in databases such as Springer, ScienceDirect, Scopus, and John Wiley to obtain the latest findings regarding the medical applications of cyanobacteria. Utilizing the MeSH database, appropriate keywords were identified, leading to the selection of 66 recent reviews and research articles for comprehensive analysis.
Findings: Biologically active molecules derived from cyanobacteria have a wide range of activities, including antimicrobial, antibacterial, antiviral, anti-inflammatory, antitumor, antimalarial, immunosuppressive, anti-HIV, and protease inhibitory activities. Indeed, cyanobacteria serve as a valuable microbial source for the production of novel drugs, requiring only basic minerals for growth.
Conclusion: Modern techniques and microwave-assisted extraction methods enable the rapid isolation of bioactive compounds from cyanobacteria. These approaches play a pivotal role in in developing new therapies and further utilization of cyanobacteria in advancing green technologies in the future.

کلیدواژه‌ها [English]

  • Cyanobacteria
  • Biotechnology
  • Pharmaceutical preparations
  • Therapeutics

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مجله دانشکده پزشکی اصفهان
دوره 42، شماره 755
هفته 3، فروردین
فروردین و اردیبهشت 1403
صفحه 69-83

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سابقه مقاله

  • تاریخ دریافت: 25 آذر 1402
  • تاریخ پذیرش: 22 اردیبهشت 1403

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