Isfahan University of Medical Sciences Journal of Isfahan Medical School 1027-7595 27 100 2009 11 22 Antifungal activity of Ferula assa-foetida Against clinical agents of Mucormycosis Antifungal activity of Ferula assa-foetida Against clinical agents of Mucormycosis 582 588 13060 FA Rasoul Mohammadi PhD student, Department of Medical Mycology, Tarbiat Modares University, Tehran 0000-0002-8220-4511 Asghar Sepahvand PhD student, Department of Medical Mycology, Tarbiat Modares University, Tehran Shahla Roodbar Mohammadi Assistant Professor, Department of Medical Mycology, Tarbiat Modares University, Tehran Shahla Shadzi Professor, Department of Medical Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan Hajar Mirsafaei Student of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan Razieh Noor Shargh Student of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan Journal Article 2010 11 07 Background : Mucormycosis is an acute fungal disease and opportunistic infection caused by Mucorals order which has a wide geographic distribution. The major predisposing factors for Mucormycosis are hyperglycemia, metabolic acidosis, Supraphysrologic dosis of adrenal Corticosteroids and Leukemia. Ferula assa- foetida is the gum resin obtained from the dried roots of this plant. It has antispasm and antimicrobial effects. It is used in the treatment of asthma and Sarcomas.Since it’s antibacterial effects was proven,but antifungal studies of this essential oil is very limited,so this study was aimed for this defect. Methods: In this study, we used broth microdilution method. Essential oil of the plants was extracted by means of clevenger apparatus and used on isolates in microplate wells and their MIC was calculated. Ressult: The number of samples was twenty five. Seven isolates didn’t grow up to the dilution of 1/8th of essential oil, ten isolates up to 1/16th and eight isolates up to 1/32nd . Conclusion: Because of the nephrotoxicity effects of amphotericin B, the evaluation of in vivo antifungal activity of Ferula assa-foetida essential oil (Ferula assa-foetida essential oil has not nephrotoxicity effects), drug resistance and the effect of pH and temperature on activity of this essential oil, is recommended. Key words: Ferula assa–foetida, Mucormycosis, Antifungal activity, Essential oil. Background : Mucormycosis is an acute fungal disease and opportunistic infection caused by Mucorals order which has a wide geographic distribution. The major predisposing factors for Mucormycosis are hyperglycemia, metabolic acidosis, Supraphysrologic dosis of adrenal Corticosteroids and Leukemia. Ferula assa- foetida is the gum resin obtained from the dried roots of this plant. It has antispasm and antimicrobial effects. It is used in the treatment of asthma and Sarcomas.Since it’s antibacterial effects was proven,but antifungal studies of this essential oil is very limited,so this study was aimed for this defect. Methods: In this study, we used broth microdilution method. Essential oil of the plants was extracted by means of clevenger apparatus and used on isolates in microplate wells and their MIC was calculated. Ressult: The number of samples was twenty five. Seven isolates didn’t grow up to the dilution of 1/8th of essential oil, ten isolates up to 1/16th and eight isolates up to 1/32nd . Conclusion: Because of the nephrotoxicity effects of amphotericin B, the evaluation of in vivo antifungal activity of Ferula assa-foetida essential oil (Ferula assa-foetida essential oil has not nephrotoxicity effects), drug resistance and the effect of pH and temperature on activity of this essential oil, is recommended. Key words: Ferula assa–foetida, Mucormycosis, Antifungal activity, Essential oil. https://jims.mui.ac.ir/article_13060_c78b93d4d09ef6235e9d494b3534420e.pdf