Isfahan University of Medical Sciences Journal of Isfahan Medical School 1027-7595 28 107 2010 06 22 Implantation of small intestinal mucosa in colonic submucosal bed in cat Implantation of small intestinal mucosa in colonic submucosal bed in cat 13281 FA Gholamreza Mohajeri Assistant Professor of Thoracic Surgery, Department of Surgery, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan 0000-0001-5012-5782 Mansoor Safaei Associated Professor of Vascular Surgery, Department of Surgery, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan Reza Eshraghi Samani General Surgeon, Department of Surgery, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Roohallah Sobhani General Surgeon, Department of Surgery, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Journal Article 2011 02 17 Background: Short bowel syndrome is arbitrarily defined as the presence of less than 200 cm of residual small bowel in adults. Most of the patients are dependent to total parenteral nutrition (TPN), rather than high cost, it has many complications such as sepsis. The surgical procedures are associated with intestinal obstruction and their efficacy needs to be defined. This study was performed to implant small intestinal mucosa in colonic submucosal bed in order to find a new treatment for the patients suffering from short bowel syndrome and dependent to TPN. Methods: This study was experimental and performed in Torabinejad Research Center in Isfahan University of Medical Sciences in 2008. Eight Persian male cats was studied and during laparotomy a 1 × 1 cm mucosal patch of terminal ileum was implanted in submucosa of the colon. After 14 days, second laparotomy was done and the colon was examined hystologically. Findings: In 7 cats, colonic mucosal structure was seen in the site of the patch (87.5%) and in 1 cat, ileal mucosal structure was seen (12.5%). Conclusion: According to the results, implantation of small intestinal mucosa in colonic submucosal bed was unsuccessful but possibly it may be a new alternative treatment for short bowel syndrome. Background: Short bowel syndrome is arbitrarily defined as the presence of less than 200 cm of residual small bowel in adults. Most of the patients are dependent to total parenteral nutrition (TPN), rather than high cost, it has many complications such as sepsis. The surgical procedures are associated with intestinal obstruction and their efficacy needs to be defined. This study was performed to implant small intestinal mucosa in colonic submucosal bed in order to find a new treatment for the patients suffering from short bowel syndrome and dependent to TPN. Methods: This study was experimental and performed in Torabinejad Research Center in Isfahan University of Medical Sciences in 2008. Eight Persian male cats was studied and during laparotomy a 1 × 1 cm mucosal patch of terminal ileum was implanted in submucosa of the colon. After 14 days, second laparotomy was done and the colon was examined hystologically. Findings: In 7 cats, colonic mucosal structure was seen in the site of the patch (87.5%) and in 1 cat, ileal mucosal structure was seen (12.5%). Conclusion: According to the results, implantation of small intestinal mucosa in colonic submucosal bed was unsuccessful but possibly it may be a new alternative treatment for short bowel syndrome. https://jims.mui.ac.ir/article_13281_44680b5f7cefd57a0e580cfc11a9308f.pdf