Isfahan University of Medical Sciences Journal of Isfahan Medical School 1027-7595 29 127 2011 03 21 Comparison of Relative Frequency of Human Papillomatous Virus by Using of Immiunohistochemistry Method between Patients with Prostatic Adenocarcinoma or Benign Prostatic Hyperplasia Comparison of Relative Frequency of Human Papillomatous Virus by Using of Immiunohistochemistry Method between Patients with Prostatic Adenocarcinoma or Benign Prostatic Hyperplasia 80 85 13373 FA Mojgan Mokhtari Associate Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Faegheh Taghizadeh Pathologist, Isfahan University of Medical Sciences, Isfahan, Iran. Esmaeil Rouzbahani Orthopedic Surgeon, Isfahan University of Medical Sciences, Isfahan, Iran Tahmineh Narimani Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Journal Article 2011 04 17 Background: Prostatic Adenocarcinoma is the most prevalent cancer in men and cause of death in them. Many risk factors have been recognized like as Human Papillomatous Virus (HPV) which could be detected better by immiunohistochemistry (IHC) method. Our aim was comparing the relative frequency of HPV in patients with adenocarcinoma or benign prostatic hyperplasia (BPH).Methods: In this study, presence of HPV in 120 cases (90 with BPH and 30 with adenocarcinoma) was detected by IHC.Finding: As a whole, 4 patients (3 in adenocarcinoma and 1 in BPH group) were HPV positive (detected by IHC method). The mean age was in 61.75 and 68.51 years in HPV positive and HPV negative groups, respectively. Correlation between age and HPV was not significant. Correlation between HPV and adenocarcinoma was meaningful (P = 0.048).Conclusion: In this study, 3.3% of patients were HPV positive. HPV is a risk factor for prostat hyperplasia and also its conversion to malignancy. HPV infections shold be diagnosed and treated in early stages to reduce prevalence of adenocarcinoma and other complications.          Background: Prostatic Adenocarcinoma is the most prevalent cancer in men and cause of death in them. Many risk factors have been recognized like as Human Papillomatous Virus (HPV) which could be detected better by immiunohistochemistry (IHC) method. Our aim was comparing the relative frequency of HPV in patients with adenocarcinoma or benign prostatic hyperplasia (BPH).Methods: In this study, presence of HPV in 120 cases (90 with BPH and 30 with adenocarcinoma) was detected by IHC.Finding: As a whole, 4 patients (3 in adenocarcinoma and 1 in BPH group) were HPV positive (detected by IHC method). The mean age was in 61.75 and 68.51 years in HPV positive and HPV negative groups, respectively. Correlation between age and HPV was not significant. Correlation between HPV and adenocarcinoma was meaningful (P = 0.048).Conclusion: In this study, 3.3% of patients were HPV positive. HPV is a risk factor for prostat hyperplasia and also its conversion to malignancy. HPV infections shold be diagnosed and treated in early stages to reduce prevalence of adenocarcinoma and other complications.          https://jims.mui.ac.ir/article_13373_0a4be74a9612071c7992274538563b78.pdf