Isfahan University of Medical Sciences Journal of Isfahan Medical School 1027-7595 29 134 2011 05 22 Intracranial Extramedullary Hematopoiesis in a Patient with Intermediate B-Thalassemia Intracranial Extramedullary Hematopoiesis in a Patient with Intermediate B-Thalassemia 403 408 13405 FA Parvin Mahzuni Associate Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Homayoon Tabesh Assistant Professor, Department of Neurosurgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Mojgan Mokhtari Assistant Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Ahmad Shekarchizadeh Assistant Professor, Department of Neurosurgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Azadeh Karami Resident, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Journal Article 2011 03 15 Background: Extramedullary hematopoiesis refers to formation of hematopoietic tissue and it is a compensatory phenomen in hematologic disease like congenital hemolytic anemia, myelofibrosis, pernicious anemia & Bone marrow infiltration secondary to malignancies. It has been reported in many sites but the most common sites are liver, spleen & lymph node.Case Report: A 34-year-old man with intermediate B-thalassemia had chronic headache and progressive loss of visual function. In CT scan a lobulated, non homogenous hyperdense mass was seen in left occipital horn with massive surrounding edema. In histologic examination the presence of hematopoietic tissue in brain parenchyma was confirmed. Background: Extramedullary hematopoiesis refers to formation of hematopoietic tissue and it is a compensatory phenomen in hematologic disease like congenital hemolytic anemia, myelofibrosis, pernicious anemia & Bone marrow infiltration secondary to malignancies. It has been reported in many sites but the most common sites are liver, spleen & lymph node.Case Report: A 34-year-old man with intermediate B-thalassemia had chronic headache and progressive loss of visual function. In CT scan a lobulated, non homogenous hyperdense mass was seen in left occipital horn with massive surrounding edema. In histologic examination the presence of hematopoietic tissue in brain parenchyma was confirmed. https://jims.mui.ac.ir/article_13405_0125141592fa9ededc665c55d9958f69.pdf