Isfahan University of Medical Sciences Journal of Isfahan Medical School 1027-7595 29 154 2011 10 23 Evaluation of the Distribution of Topical Bupivacaine in Epidural anesthesia with MRI Evaluation of the Distribution of Topical Bupivacaine in Epidural anesthesia with MRI 1334 1340 13520 FA Hamid Saryazdi Assistant Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Gholamreza Khalili Assistant Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Masoud Shahbazi Resident, Department of Anesthesiology, School of Medicine And Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran Saeed Abbasi Assistant Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0003-0930-5698 Gholamreza Mohajeri Assistant Professor, Department of Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0001-5012-5782 Ali Hekmatnia Assosciate Professor, Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Journal Article 2011 07 15 Background: Epidural anesthesia is one of the most common anesthesia methods, in surgical procedures. Since there is not any exact information about the spread of local anesthetic substances in epidural area, in this study we evaluated the distribution of Bupivacaine in epidural anesthesia.Methods: After giving necessary information and signing the permission form, 24 patient candidates for elective cholecystectomy were enrolled in the study. They were selected by simple probable method. Before the surgery in sitting position by aseptic technique 8 CC bupivacaine plus 1 CC magnevist (as contrast) injected to the epidural space. Then patient transferred to the MRI room and images prepared by MRI studied by the radiologist. Heart rate, systolic and diastolic blood pressure and mean arterial pressure were measured at the injection time and 5 and 10 minute later.Findings: Among 24 patients (15 women and 9 men) we recognized that the mean distribution of applied medications in men and women were 4.8 and 5.5 level respectivly (P < 0.05). There was not any relationship between local anesthetic distribution with age and weight. Height and body mass index had a significant convert correlation with the distribution of bupivacaine. Heart rate, systolic and diastolic blood pressure and mean arterial pressure were significantly decreased in studied times.  Conclusion: We found that the distribution of bupivacaine among men are less than women. The distribution of bupivacaine in cephalad direction was more than codal direction. Background: Epidural anesthesia is one of the most common anesthesia methods, in surgical procedures. Since there is not any exact information about the spread of local anesthetic substances in epidural area, in this study we evaluated the distribution of Bupivacaine in epidural anesthesia.Methods: After giving necessary information and signing the permission form, 24 patient candidates for elective cholecystectomy were enrolled in the study. They were selected by simple probable method. Before the surgery in sitting position by aseptic technique 8 CC bupivacaine plus 1 CC magnevist (as contrast) injected to the epidural space. Then patient transferred to the MRI room and images prepared by MRI studied by the radiologist. Heart rate, systolic and diastolic blood pressure and mean arterial pressure were measured at the injection time and 5 and 10 minute later.Findings: Among 24 patients (15 women and 9 men) we recognized that the mean distribution of applied medications in men and women were 4.8 and 5.5 level respectivly (P < 0.05). There was not any relationship between local anesthetic distribution with age and weight. Height and body mass index had a significant convert correlation with the distribution of bupivacaine. Heart rate, systolic and diastolic blood pressure and mean arterial pressure were significantly decreased in studied times.  Conclusion: We found that the distribution of bupivacaine among men are less than women. The distribution of bupivacaine in cephalad direction was more than codal direction. https://jims.mui.ac.ir/article_13520_2410f01cc34c57702bbec8f884db18d5.pdf