Isfahan University of Medical Sciences Journal of Isfahan Medical School 1027-7595 29 161 2011 12 22 Comparative Analysis of APC Tumor Suppressor Protein Expression in Cancerous and Normal Colorectal Specimens by Immunohistochemistry Comparative Analysis of APC Tumor Suppressor Protein Expression in Cancerous and Normal Colorectal Specimens by Immunohistochemistry 1815 1821 13575 FA Mehdi Nikbakht Dastjerdi Associate Professor, Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Meisam Mahmoodi Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Journal Article 2011 08 15 Background: APC is a tumor-suppressor protein. To evaluate the correlation between APC expression and pathogenesis of colorectal cancer, we investigated the expression of this protein in cancerous and normal colorectal tissues.Methods: APC expression was evaluated in 50 pairs of primary colorectal cancers and corresponding normal colorectal tissues using immunohistochemical staining on paraffin-embedded sections.Findings: APC was expressed in all tissues. It was down-regulated in the colorectal cancer specimens compared with the matched normal tissues (P < 0.001). Conclusion: APC expression may be a favorable biologic marker and a useful prognostic indicator in patients with colorectal cancer. Background: APC is a tumor-suppressor protein. To evaluate the correlation between APC expression and pathogenesis of colorectal cancer, we investigated the expression of this protein in cancerous and normal colorectal tissues.Methods: APC expression was evaluated in 50 pairs of primary colorectal cancers and corresponding normal colorectal tissues using immunohistochemical staining on paraffin-embedded sections.Findings: APC was expressed in all tissues. It was down-regulated in the colorectal cancer specimens compared with the matched normal tissues (P < 0.001). Conclusion: APC expression may be a favorable biologic marker and a useful prognostic indicator in patients with colorectal cancer. https://jims.mui.ac.ir/article_13575_0a8a64171a9145f6a47e5b3544632e3b.pdf