Isfahan University of Medical Sciences Journal of Isfahan Medical School 1027-7595 29 173 2012 02 20 The Association of Zinc Serum Level with Age, Sex and Disease Severity in Acne Vulgaris Patients The Association of Zinc Serum Level with Age, Sex and Disease Severity in Acne Vulgaris Patients 3008 3015 13703 FA Gholam Hossein Ghafarpour Associate Professor, Skin and Stem Cell Research Center And Department of Dermatology, Hazrat Rasoul Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran Vahid Ebrahimi Resident, Skin Disease and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan And Department of Dermatology, Hazrat Rasoul Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran Mir Hadi Aziz Jalali Associate Professor, Skin and Stem Cell Research Center And Department of Dermatology, Hazrat Rasoul Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran Journal Article 2012 03 12 Background: Acne vulgaris is a chronic inflammatory disease of pilosebaceous follicles. It is one of the most important skin disorders during adolescence. Zinc is one of essential trace elements in the body that has major roles in maintaining health. The main objectives of this study were to measure zinc serum levels and assess its relationship with age, sex, and disease severity in patients with acne vulgaris.Methods: 100 consecutive patients with acne vulgaris referred to Hazrat-Rassoul-Akram hospital in 2010 were enrolled as a non-random sample. Fasting blood specimens were taken at 9 am and serum zinc level was measured by atomic absorption spectrophotometry method.Findings: Mean serum zinc level of acne patients in this study was 106.78 ± 22.2 µg/dl. Mean levels of serum zinc were significantly lower in women compared to men (104.54 ± 2.72 µg/dl and 115.19 ±1.71 µg/dl, respectively; P < 0.05). There was no significant correlation between serum zinc and acne history or severity. Conclusion: According to our findings, there is no link between serum zinc level and acne severity. Further evaluation of other contributing factors is suggested. Background: Acne vulgaris is a chronic inflammatory disease of pilosebaceous follicles. It is one of the most important skin disorders during adolescence. Zinc is one of essential trace elements in the body that has major roles in maintaining health. The main objectives of this study were to measure zinc serum levels and assess its relationship with age, sex, and disease severity in patients with acne vulgaris.Methods: 100 consecutive patients with acne vulgaris referred to Hazrat-Rassoul-Akram hospital in 2010 were enrolled as a non-random sample. Fasting blood specimens were taken at 9 am and serum zinc level was measured by atomic absorption spectrophotometry method.Findings: Mean serum zinc level of acne patients in this study was 106.78 ± 22.2 µg/dl. Mean levels of serum zinc were significantly lower in women compared to men (104.54 ± 2.72 µg/dl and 115.19 ±1.71 µg/dl, respectively; P < 0.05). There was no significant correlation between serum zinc and acne history or severity. Conclusion: According to our findings, there is no link between serum zinc level and acne severity. Further evaluation of other contributing factors is suggested. https://jims.mui.ac.ir/article_13703_967162a0b2dc0483ad3d0f47dfb1e9ac.pdf